Metabolism - Clinical and Experimental
Volume 44, Issue 8 , Pages 996-999 , August 1995

Elevated plasma ceruloplasmin in insulin-dependent diabetes mellitus: Evidence for increased oxidative stress as a variable complication

  • John Cunninghamn

      Affiliations

    • Corresponding Author InformationAddress reprint requests to John Cunningham, PhD, Department of Nutrition, Chenoweth Lab, Box 31420, University of Massachusetts, Amherst, MA 01003-1420.
    • Department of Nutrition, University of Massachusetts, Amherst, USA
    • Shriners Burns Institute, Boston, MA, USA
    • Children's Hospital Oakland Research Institute, Oakland, CA, USA
    • ,
  • Marlene Leffell

      Affiliations

    • Department of Nutrition, University of Massachusetts, Amherst, USA
    • Shriners Burns Institute, Boston, MA, USA
    • Children's Hospital Oakland Research Institute, Oakland, CA, USA
    • ,
  • Patricia Mearkle

      Affiliations

    • Department of Nutrition, University of Massachusetts, Amherst, USA
    • Shriners Burns Institute, Boston, MA, USA
    • Children's Hospital Oakland Research Institute, Oakland, CA, USA
    • ,
  • Paul Harmatz

      Affiliations

    • Department of Nutrition, University of Massachusetts, Amherst, USA
    • Shriners Burns Institute, Boston, MA, USA
    • Children's Hospital Oakland Research Institute, Oakland, CA, USA

Received 11 June 1994 ,Accepted 5 December 1994.

References 

  1. O'Dell B. Copper. In:  Brown ML editors. Present Knowledge in Nutrition. ed 6. Washington, DC: ILSI Nutrition Foundation; 1990;p. 261–267
  2. Harris ED. The transport of copper. Prog Clin Biol Res. 1993;380:163–173
  3. Ryden L. Ceruloplasmin. In: ed 8.  Lontie R editors. Copper Proteins and Copper Enzymes. vol 3:Boca Raton, FL: CRC; 1984;p. 37–100
  4. Samokyszyn VM, Reif DW, Miller DM, et al.  Effects of ceruloplasmin on superoxide-dependent iron release from ferritin and lipid peroxidation. Free Radical Res Commun. 1991;12–13:153–159
  5. Monboisse JC, Gillery P, Maquart FX, et al.  Production of superoxide anion by glycated proteins: Involvement in complications of diabetes mellitus. In: ed 8.  Emerit I, et al. editor. Antioxidants in Therapy; Preventive Medicine. vol 1:New York, NY: Plenum; 1990;p. 551–554
  6. Sato Y, Hotta N, Sakamoto N, et al.  Lipid peroxide level in plasma of diabetic patients. Biochem Med. 1979;21:104–107
  7. Walter RM, Uriu-Hare JY, Lewis Olin K, et al.  Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care. 1991;14:1050–1056
  8. McMillan DE. Increased levels of acute-phase serum proteins in diabetes. Metabolism. 1989;38:1042–1046
  9. Raz I, Havivi E. Trace elements in blood cells of diabetic subjects. Diabetes Res. 1989;10:21–24
  10. Sjogren A, Edvinsson L, Floren C-H, et al.  Zinc and copper in striated muscle and body fluids from subjects with diabetes mellitus type I. Nutr Res. 1986;6:147–154
  11. Awadallah R, El Dessoukey EA, Doss H, et al.  Blood reduced glutathione, serum ceruloplasmin and mineral changes in juvenile diabetes. Z Ernahrungswiss. 1978;17:79–83
  12. Sinha SN, Gabrieli ER. Serum copper and zinc levels in various pathologic conditions. Am J Clin Pathol. 1970;54:570–577
  13. Pidduck HG, Wren PJJ, Price Evans DA. Plasma zinc and copper in diabetes mellitus. Diabetes. 1970;19:234–239
  14. Jones AF, Wilkes JW, Jennings PE, et al.  Serum antioxidant activity in diabetes mellitus. Diabetes Res. 1988;7:89–92
  15. Majewski BB, Barter S, Rhodes EL. Serum alpha 2 globulin levels in granuloma annulare and necrobiosis lipoidica. Br J Dermatol. 1981;105:557–562
  16. Jonsson A, Whales JK. Blood glycoprotein levels in diabetes mellitus. Diabetologia. 1976;12:245–250
  17. Collier A, Wilson R, Bradley H, et al.  Free radical activity in type 2 diabetes. Diabetic Med. 1990;7:27–30
  18. Awadallah R, El Dessoukey EA, Doss H, et al.  Blood reduced glutathione, pyruvic acid, citric acid, ceruloplasmin oxidase activity and certain mineral changes in diabetes mellitus before and after treatment. Z Ernahrungswiss. 1978;17:72–78
  19. Cheta D, Mihalache N, Santu E, et al.  Study of some serum protein fractions in various clinical forms of diabetes mellitus. Med Interne. 1981;19:55–61
  20. Martin Mateo MC, Bustamante JB, Cantalapiedra MAG. Serum zinc, copper and insulin in diabetes mellitus. Biomedicine. 1978;29:56–58
  21. Jacob RA, Skala JH, Omaye ST, et al.  Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. J Nutr. 1987;117:2109–2115
  22. Harris ED, Percival SS. Copper transport: Insights into a ceruloplasmin-based delivery system. Adv Med Biol. 1989;258:95–102
  23. Holtzman NA, Gaumnitz BM. Studies on the rate and turnover of ceruloplasmin and apoceruloplasmin in rat plasma. J Biol Chem. 1970;245:2354–2358
  24. Cunningham JJ, Mearkle PL, Brown RG. Vitamin C: An aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr. 1994;13:344–350
  25. Omaye SJ, Turnbull TD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol. 1979;62:1–11
  26. Ravin HA. An improved colorimetric enzymatic assay of ceruloplasmin. J Lab Clin Med. 1961;58:161–168
  27. Cunningham JJ, Fu A, Mearkle PL, et al.  Hyperzincuria in individuals with insulin-dependent diabetes mellitus: Concurrent zinc status and the effect of high-dose zinc supplementation. Metabolism. 1994;43:1558–1562
  28. Brewer GJ, Hill GM, Dick RD, et al.  Treatment of Wilson's disease with zinc. III. Prevention of reaccumulation of hepatic copper. J Lab Clin Med. 1987;109:526–531
  29. Finley EB, Cerlewski FL. Influence of ascorbic acid supplementation on copper status in young adult men. Am J Clin Nutr. 1983;37:553–556

☆ Supported by funds from the Shriners Hospitals for Crippled Children (project no. 15851) and Hoffrnann-LaRoche.

PII: 0026-0495(95)90095-0

Metabolism - Clinical and Experimental
Volume 44, Issue 8 , Pages 996-999 , August 1995

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