Metabolism - Clinical and Experimental
Volume 44, Issue 8 , Pages 1013-1015 , August 1995

Testosterone treatment in adolescent boys with constitutional delay of growth and development

  • Ashraf T. Soliman

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ashraf T. Soliman, MD, Chief, Pediatric Endocrinology, Royal Hospital, PO Box 1331 Seeb, Code 111, Muscat, Oman
    • Departments of Pediatrics and Medicine, University of Alexandria, College of Medicine, Alexandria, Egypt
    • Department of Pediatric Endocrinology, Royal Hospital, Muscat, Oman, Kingdom of Saudi Arabia
    • ,
  • Mohammed M. Abdul Khadir

      Affiliations

    • Departments of Pediatrics and Medicine, University of Alexandria, College of Medicine, Alexandria, Egypt
    • Department of Pediatric Endocrinology, Royal Hospital, Muscat, Oman, Kingdom of Saudi Arabia
    • ,
  • Maurice Asfour

      Affiliations

    • Departments of Pediatrics and Medicine, University of Alexandria, College of Medicine, Alexandria, Egypt
    • Department of Pediatric Endocrinology, Royal Hospital, Muscat, Oman, Kingdom of Saudi Arabia

Received 30 June 1994 ,Accepted 21 October 1994.

References 

  1. Gordon M, Crouthamel C, Post EM, et al.  Psychosocial aspects of constitutional short stature: Social competence, behavior problems, self-esteem, and family functioning. J Pediatr. 1982;101:477–480
  2. Galatzer A, Rosenblith E, Laron Z. Psychological and rehabilitational aspects of short stature and delayed puberty. In:  Gedda L,  Parisi P editor. Auxology: Human Growth in Health and Disease. London, UK: Academic; 1978;
  3. Marti-Henneberg C, Niirianen AK, Rappaport R. Oxandrolone treatment of constitutional short stature in boys during adolescence: Effect on linear growth, bone age, pubic hair and testicular development. J Pediatr. 1975;86:783–787
  4. Kaplan JG, Moshang T, Bernstein R. Constitutional delay of growth and development: Effect of treatment with androgens. J Pediatr. 1973;82:38–42
  5. Richman RA, Kitsch LR. Testosterone treatment in adolescent boys with constitutional delay in growth and development. N Engl J Med. 1988;319:1563–1567
  6. Rosenfeld RG, Northcraft GB, Hintz RL. A prospective, randomized study of testosterone treatment of constitutional delay of growth and development in male adolescents. Pediatrics. 1982;69:681–687
  7. Kelch RP, Grumbach MM, Kaplan SL. Studies on the mechanism of puberty in man. In:  Saxena BB,  Beling C,  Gandy HM editor. Gonadotropins. New York, NY: Wiley-Interscience; 1972;p. 524–534
  8. Winter JSD, Faiman C. Pituitary-gonadal relations in male children and adolescents. Pediatr Res. 1972;6:126–131
  9. Greulich WW, Pyle SI. Radiographic Atlas of Skeletal Development of the Hand and Wrist. ed 2. Stanford, CA: Stanford University Press; 1959;
  10. Ulloa-Aguirre A, Blizzard RM, Garcia-Rubi E, et al.  Testosterone and oxandrolone, a nonaromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency of the GH half-life. J Clin Endocrinol Metab. 1990;71:846–850
  11. Binoux M, Gourmelen M. Statural development parallels IGF-I levels in subjects of constitutionally variant short stature. Acta Endocrinol (Copenh). 1987;114:524–528
  12. Brook CGD, Hindmarsh PC. The somatotropic axis in puberty. Endocrinol Metab Clin North Am. 1992;21:767–782

PII: 0026-0495(95)90098-5

Metabolism - Clinical and Experimental
Volume 44, Issue 8 , Pages 1013-1015 , August 1995

Article Tools