Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1397-1400 , November 1995

Insulin sensitivity, insulin secretion, and glucose effectiveness in obese subjects: A minimal model analysis

  • Ataru Taniguchi

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ataru Taniguchi, MD, First Department of Internal Medicine, Kansai-Denryoku Hospital, 1-7 Fukushima 2-chome, Fukushima-ku, Osaka 553, Japan.
    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Yoshikatu Nakai

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Kentaro Doi

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Hiroaki Fukuzawa

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Mitsuo Fukushima

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Hitomi Kawamura

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Kumpei Tokuyama

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Masashige Suzuki

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Junzo Fujitani

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Hiroaki Tanaka

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan
    • ,
  • Itaru Nagata

      Affiliations

    • First Department of Internal Medicine, Kansai-Denyoku Hospital, Osaka, Japan
    • Division of the Science of Nursing, College of Medical Technology, Kyoto University, Kyoto, Japan
    • Second Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
    • Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan
    • Department of Exercise Physiology, School of Physical Education, Fukuoka University, Fukuoka, Japan

Received 19 May 1994 ,Accepted 14 March 1995.

References 

  1. Kolterman OG, Insel J, Saekow M, et al.  Mechanism of insulin resistance in human obesity. In: Evidence for receptor and postreceptor defects. ed 2. J Clin Invest. 65:1980;p. 1272–1284
  2. Bonadonna RC, Groop L, Kraemer N, et al.  Obesity and insulin resistance in humans: A dose-response study. Metabolism. 1990;39:452–459
  3. Kissebah AH, Peiris AN. Biology of regional body fat distribution: Relationship to non—insulin-dependent diabetes mellitus. Diabetes Metab Rev. 1989;5:83–109
  4. Unger RH, Grundy S. Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes. Diabetologia. 1985;28:119–121
  5. Golay A, Chen Y-DI, Reaven GM. Effect of differences in glucose tolerance on insulin's ability to regulate carbohydrate and free fatty acid metabolism in obese individuals. J Clin Endocrinol Metab. 1986;62:1081–1088
  6. Reaven GM, Hollenbeck CB, Chen Y-DI. Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance. Diabetologia. 1989;42:52–55
  7. Taniguchi A, Nakai Y, Fukushima M, et al.  Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: A minimal model analysis. Metabolism. 1994;43:714–718
  8. Bergman RN, Ider YZ, Bowden CR, et al.  Quantitative estimation of insulin sensitivity. Am J Physiol. 1979;236:E667–E677
  9. Bergman RN. Toward physiological understanding of glucose tolerance: Minimal-model approach. Diabetes. 1989;38:1512–1527
  10. Finegood DT, Hramiak IM, Dupre J. A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1990;70:1538–1549
  11. Pacini G, Bergman RN. MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed. 1986;23:113–122
  12. Welch S, Gebhart SSP, Bergman RN, et al.  Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab. 1990;71:1508–1518
  13. Taniguchi A, Nakai Y, Fukushima M, et al.  Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes. 1992;41:1540–1546
  14. Fukushima M, Nakai Y, Taniguchi A, et al.  Insulin sensitivity, insulin secretion and glucose effectiveness in anorexia nervosa: A minimal model analysis. Metabolism. 1993;42:1164–1168
  15. Tokuyama K, Higaki Y, Fujitani J, et al.  Intravenous glucose tolerance test—derived glucose effectiveness in physically trained humans. Am J Physiol. 1993;265:E298–E303
  16. Marchesini G, Pacini G, Bianchi G, et al.  Glucose disposal, B-cell secretion, and hepatic insulin extraction in cirrhosis: A minimal model assessment. Gastroenterology. 1990;99:1715–1722
  17. Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest. 1981;68:1456–1467
  18. Chen M, Bergman RN, Pacini G, et al.  Pathogenesis of age-related glucose intolerance in man: Insulin resistance and B-cell function. J Clin Endocrinol Metab. 1985;60:13–20
  19. Valdes CT, Elkind-Hirsch E. Intravenous glucose tolerance test—derived insulin sensitivity changes during the menstrual cycle. J Clin Endocrinol Metab. 1991;72:642–646
  20. Chen M, Bergman RN, Porte D. Insulin resistance and B-cell dysfunction in aging: The importance of dietary carbohydrate. J Clin Endocrinol Metab. 1988;67:951–957
  21. Nakai Y, Taniguchi A, Fukushima M, et al.  Insulin sensitivity during very-low-calorie diets assessed by minimal modeling. Am J Clin Nutr. 1992;56:179S–181S
  22. Ader M, Pacini G, Yang YJ, et al.  Importance of glucose per se to intravenous glucose tolerance. In: Comparison of the minimal-model prediction with direct measurements. ed 2. Diabetes. 34:1985;p. 1092–1103
  23. Bergman RN, Prager R, Volund A, et al.  Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 1987;79:790–800
  24. Beard JC, Bergman RN, Ward WK, et al.  The insulin sensitivity index in nondiabetic man. In: Correlation between clamp-derived and IVGTT-derived values. ed 2. Diabetes. 35:1986;p. 362–369
  25. Kahn SE, Bergman RN, Schwartz MW, et al.  Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol. 1992;262:E518–E523
  26. Kahn SE, Klaff LJ, Schwartz MW, et al.  Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J Clin Endocrinol Metab. 1990;7:994–1002
  27. Osei K, Cottrell DA, Orabella MM. Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care. 1991;14:890–896
  28. Martin BC, Warram JH, Krolewski AS, et al.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study. Lancet. 1992;340:925–929
  29. World Health Organization . Diabetes mellitus: Report of a WHO study group. WHO Tech Rep Ser no. 727. 1985;
  30. Press WH, Flannery BP, Teukolsky SA, et al.  Numerical Recipes in Pascal. New York, NY: Cambridge University Press; 1989;
  31. Winer BJ. Statistical Principles in Experimental Design. In: ed 2. New York, NY: McGraw-Hill; 1971;p. 514–603
  32. Lovejoy J, DiGirolamo M. Habitual dietary intake and insulin sensitivity in lean and obese adults. Am J Clin Nutr. 1992;55:1174–1179
  33. Leahy JL. Natural history of B-cell dysfunction in NIDDM. Diabetes Care. 1990;13:992–1010
  34. Kahn SE, Prigeon RL, McCulloch DK, et al.  Quantification of the relationship between insulin sensitivity and B-cell function in human subjects. In: Evidence for a hyperbolic function. ed 3. Diabetes. 42:1993;p. 1663–1672
  35. Banerji MA, Lebovitz HE. Insulin-sensitive and insulin-resistant variants in NIDDM. Diabetes. 1989;38:784–792
  36. Keen H, Jarrett RJ, McCartney P. The ten-year follow-up of the Bedford Survey (1962–1972): Glucose tolerance and diabetes. Diabetologia. 1982;22:73–78
  37. King H, Zimmet P, Raper LR, et al.  The natural history of impaired glucose tolerance in the Micronesian population of Nauru: A six-year follow-up study. Diabetologia. 1984;26:39–43
  38. Sasaki A, Suzuki T, Horiuchi N. Development of diabetes in Japanese subjects with impaired glucose tolerance: A seven year follow-up study. Diabetologia. 1982;22:154–157

PII: 0026-0495(95)90136-1

Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1397-1400 , November 1995

Article Tools