Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1417-1421 , November 1995

Hemostatic function in young subjects with central obesity: Relationship with left ventricular function

Received 1 August 1994 ,Accepted 9 March 1995.

References 

  1. Licata G, Corrao S, Parrinello G, et al.  Obesity and cardiovascular diseases. Ann Ital Med Int. 1994;9:29–32
  2. Must A, Jacques PF, Dallal GE, et al.  Long-term morbidity and mortality of overweight adolescents. In: A follow-up of the Harvard Growth Study of 1922 to 1935. ed 3. N Engl J Med. 327:1992;p. 1350–1355
  3. Mueller WH. The changes with age of the anatomical distribution of fat. Soc Sci Med. 1982;16:191–196
  4. Deutsch MI, Mueller WH, Malina RM. Androgyny in fat patterning is associated with obesity in adolescents and young adults. Ann Hum Biol. 1985;12:275–286
  5. Meade TW, Brozovic M, Chakrabarti RR, et al.  Haemostatic function and ischaemic heart disease: Principal results of the Northwick Park Heart Study. Lancet. 1986;2:533–537
  6. ECAT Angina Pectoris Study Group . Baseline associations of haemostatic factors with extent of coronary arteriosclerosis and other coronary risk factors in 3000 patients with angina pectoris undergoing coronary angiography. Eur Heart J. 1993;14:8–17
  7. Balleisen L, Bailey J, Epping PH, et al.  Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population. I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause. Thromb Haemost. 1985;54:475–479
  8. Landin K, Stigendal L, Eriksson E, et al.  Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1. Metabolism. 1990;39:1044–1048
  9. Licata G, Scaglione R, Barbagallo M, et al.  Effect of obesity on left ventricular function studied by radionuclide angiocardiography. Int J Obes. 1991;15:295–302
  10. Licata G, Scaglione R, Paterna S, et al.  Left ventricular function response to exercise in normotensive obese subjects: Influence of degree and duration of obesity. Int J Cardiol. 1992;37:223–230
  11. Merlino G, Scaglione R, Paterna S, et al.  Lymphocyte beta adrenergic receptors in young subjects with peripheral or central obesity: Relationship with central haemodynamic and left ventricular function. Eur Heart J. 1994;15:786–792
  12. Scaglione R, Dichiara MA, Indovina A, et al.  Left ventricular diastolic and systolic function in normotensive obese subjects: Influence of degree and duration of obesity. Eur Heart J. 1992;13:738–742
  13. Beard CM, Orencia A, Kottke T, et al.  Body mass index and the initial manifestation of coronary heart disease in women aged 40–59 years. Int J Epidemiol. 1992;21:656–664
  14. Licata G, Scaglione R, Giammaresi C, et al.  No evidence of platelet activation in obesity. Thromb Haemost. 1993;70:544; (letter)
  15. Avellone G, Di Garbo V, Cordova R, et al: Coagulation, fibrinolysis and haemorrheology in premenopausal obese women with different body fat distribution. Thromb Res (in press)
  16. Crepaldi G, Belfiore S, Bosello O, et al.  In: Special Report: Italian Consensus Conference—Overweight, obesity and health. ed 3. Int J Obes. 15:1991;p. 781–790
  17. Scaglione R, Corrao S, Dichiara MA, et al: Plasma lipoprotein(a) in young obese subjects: Relationships with markers of cardiovascular risk. J Cardiovasc Risk (in press)
  18. Avellone G, Di Garbo V, Cordova R, et al.  Fibrinolysis in hypertriglyceridaemic subjects in response to venous occlusion. Blood Coag Fibrinol. 1993;4:429–433
  19. Bonow RO, Bacarach SL, Green MV, et al.  Impaired left ventricular diastolic filling in patients with coronary artery diseases: Assessment with radionuclide angiography. Circulation. 1981;64:315–323
  20. Licata G, Scaglione R, Parrinello G, et al.  Rapid left ventricular filling in untreated hypertensive subjects with or without left ventricular hypertrophy. Chest. 1992;102:1507–1511
  21. Devereux RB, Alonzo DR, Lutas EM, et al.  Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  22. Levy D, Anderson KM, Savage DD, et al.  Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors: The Framingham Heart Study. Ann Intern Med. 1988;108:7–13
  23. Manson JE, Colditz GA, Stampfer MJ, et al.  A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322:882–889
  24. Larrson B, Svardsudd K, Welin L, et al.  Abdominal a dipose tissue distribution, obesity and risk of cardiovascular disease and death: 13-year follow-up of participants in the study of men born in 1913. Br Med J. 1984;288:1401–1404
  25. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, et al.  Fibrinogen as risk factor for stroke and myocardial infarction. N Engl J Med. 1984;311:501–505
  26. Meade TW. Clotting factors and ischaemic heart disease: The epidemiological evidence. In:  Meade TW editors. Anticoagulants and Myocardial Infarction. Chichester, UK: Wiley; 1984;p. 91–112
  27. Brozovic M. Physiological mechanisms in coagulation and fibrinolysis. Br Med Bull. 1977;33:231–238
  28. Lowe GDO, Drummond MM, Lorimer AR, et al.  Relation between extent of coronary heart disease and blood viscosity. Br Med J. 1980;1:673–674
  29. Hamsten A, Walldius G, Szamosi A, et al.  Plasminogen activator inhibitor in plasma, a risk factor for recurrent myocardial infarction. Lancet. 1987;1:3–8
  30. Nilsson T, Johnson O. The extrinsic fibrinolytic system in survivors of myocardial infarction. Thromb Res. 1987;48:621–640
  31. Masuda T, Yasue H, Ogawa H, et al.  Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina. Am Heart J. 1992;124:314–319
  32. Vague P, Juhan-Vague I, Ailhaud MF, et al.  Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level and relative body weight in normal and obese subjects. Metabolism. 1986;35:250–263

☆ Supported in part by Grant No. 93.00581.PF41 from the National Research Council (CNR)-Targeted Project “Prevention and Control Disease Factors”; Subproject SP8 “Control Cardiovascular Pathology.”

PII: 0026-0495(95)90140-X

Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1417-1421 , November 1995

Article Tools