Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1422-1427 , November 1995

Insulin resistance during euglycemic clamp studies in chronically undernourished rats with mild streptozocin diabetes

  • R.H. Rao

      Affiliations

    • Corresponding Author InformationAddress reprint requests to R.H. Rao, MD, Montefiore University Hospital, 200 Lothrop St, Pittsburgh, PA 15213.

Received 20 August 1994 ,Accepted 17 March 1995.

References 

  1. Rao RH, Betschart JM, Virji MA. Effect of chronic undernutrition on hepatocyte insulin receptors in rats. Metabolism. 1991;40:1292–1297
  2. Rao RH. Adaptations in glucose homeostasis during chronic nutritional deprivation in rats: Hepatic resistance to both insulin and glucagon. Metabolism. 1995;44:817–824
  3. Heard CRC. The effects of protein-energy malnutrition on blood glucose homeostasis. World Rev Nutr Diet. 1978;30:107–147
  4. Alleyne GAO, Trust PM, Flores H, et al.  Glucose tolerance and insulin sensitivity in malnourished children. Br J Nutr. 1972;27:585–592
  5. Bowie MD. Intravenous glucose tolerance in kwashiorkor and marasmus. S Afr Med J. 1964;38:328–329
  6. Chhetri MK. Adult malnutrition—Some biochemical and hormonal aberrations. J Assoc Phys Ind. 1980;28:297–309
  7. World Health Organization Study Group on Diabetes Mellitus . WHO Tech Rep Ser. 1985;727:20–25
  8. Abu-Bakare A, Taylor R, Gill GV, et al.  Tropical or malnutrition-related diabetes: A real syndrome?. Lancet. 1986;1:1135–1138
  9. Rao RH. Is tropical pancreatic diabetes malnutrition-related?. Diabetes Care. 1993;16:941–945
  10. Rao RH. Chronic undernutrition accentuates insulin deficiency in rats with mild streptozocin diabetes. Diabetes. 1991;40:1404–1409
  11. Rao RH, Menon RK. Chronic malnutrition impairs insulin sensitivity through both receptor and post-receptor defects in rats with mild streptozocin diabetes. Metabolism. 1993;42:772–779
  12. Payne-Robinson HM, Brown R. The effect of malnutrition on insulin binding to rat erythrocytes. Br J Nutr. 1992;67:279–286
  13. Corbin J. Laboratory animal nutrition. In: ed 3.  Melby EC,  Altman NH editor. Handbook of Laboratory Animal Science. vol 3:Cleveland, OH: CRC; 1976;p. 1–21
  14. Rao RH. Changes in insulin sensitivity due to stress during repetitive sampling in anesthetized rats. Am J Physiol. 1992;262:R1033–R1039
  15. DeFronzo R, Tobin JJD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214–E223
  16. Dixon WJ. In: ed 3. BMDP Statistical Software Manual. Berkeley, CA: University of California Press; 1992;
  17. Rao RH. Fasting glucose homeostasis in the adaptation to chronic nutritional deprivation in rats. Am J Physiol. 1995;268:E873–E879
  18. Bergman RN, Hope ID, Yang YJ, et al.  Assessment of insulin sensitivity in vivo: A critical review. Diabetes Metab Rev. 1989;5:411–429
  19. Rao RH. Insulin sensitivity in spontaneously hypertensive rats. In: Differences in interpretation based on administered dose vs plasma insulin. ed 3. Diabetes. 42:1993;p. 1364–1371
  20. Crace CJ, Swenne I, Kohn PG, et al.  Protein-energy malnutrition induces changes in insulin sensitivity. Diabete Metab. 1990;16:484–491
  21. Okitolonda W, Brichard SM, Henquin JC. Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat. Diabetologia. 1987;30:946–951
  22. Swenne I, Crace CJ, Milner RDG. Persistent impairment of insulin secretory response to glucose in adult rats after limited period of protein-calorie malnutrition early in life. Diabetes. 1987;36:454–458
  23. Behar M. Protein-calorie deficits in developing countries. Ann NY Acad Sci. 1976;300:176–187
  24. Gopalan C, Rao BSN. Nutritional constraints on growth and development in current Indian dietaries. Ind J Med Res. 1971;59(suppl 1):111–122
  25. Rao RH. Insulin resistance in malnutrition diabetes: Reduced responsiveness to insulin in a rat model. In: ed 3.  Kochupillai N editors. Endocrinology, Metabolism and Diabetes. vol 1:Delhi, India: Macmillan; 1993;p. 54–61
  26. Kahn CR. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction. Metabolism. 1978;27:1893–1902
  27. Kerr DS, Stevens MCG, Robinson HM. Fasting metabolism in infants. I. Effect of severe undernutrition on energy and protein utilization. Metabolism. 1978;27:411–435
  28. Rao RH. Diabetes in the undernourished: Coincidence or consequence?. Endocr Rev. 1988;9:67–87
  29. Rossetti L, Giaccari A, Defronzo RA. Glucose toxicity. Diabetes Care. 1990;13:610–630
  30. Cerasi E, Luft R. “What is inherited—what is added” hypothesis for the pathogenesis of diabetes mellitus. Diabetes. 1967;16:615–627

PII: 0026-0495(95)90141-8

Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1422-1427 , November 1995

Article Tools