Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1428-1434 , November 1995

In vitro regulation of low-density lipoprotein receptor interaction by fatty acids

  • Judy S. Hannah

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Judy S. Hannah, PhD, Research Scientist, Medlantic Research Institute, 108 Irving St NW, Washington, DC 20010.
    • Medlantic Research Institute, Washington, DC, USA
    • Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA
  • ,
  • Kiminori Yamane

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA
  • ,
  • Elliott Berlin

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA
  • ,
  • Barbara V. Howard

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA

Received 10 September 1994 ,Accepted 9 March 1995.

References 

  1. NCEP Expert Panel . Report of the National Cholesterol Education Program Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults. Arch Intern Med. 1988;148:36–39
  2. NCEP Expert Panel . Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel II). JAMA. 1993;269:3015–3023
  3. American Heart Association . Dietary guidelines for healthy American adults: A statement for physicians and health professionals by the nutrition committee. Circulation. 1986;74:1465A–1468A
  4. Kris-Etherton PM, Krummel D, Russell ME, et al.  The effect of diet on plasma lipids, lipoproteins, and coronary disease. J Am Diet Assoc. 1988;88:1373–1400
  5. Grundy SM, Denke MA. Dietary influences on serum lipids and lipoproteins. J Lipid Res. 1990;31:1149–1172
  6. Hannah JS, Berlin E, Howard BV: Dietary effects on LDL metabolism. Nutr Res (in press)
  7. Turner JD, Le N-A, Brown WV. Effects of changing dietary fat saturation on low-density lipoprotein metabolism in man. Am J Physiol. 1981;241:E57–E63
  8. Cortese C, Levy Y, Janus ED, et al.  Modes of action of lipid-lowering diets in man: Studies of apolipoprotein B kinetics in relation to fat consumption and dietary fatty acid composition. Eur J Clin Invest. 1983;13:79–85
  9. Shepherd J, Packard CJ, Grundy SM, et al.  Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. J Lipid Res. 1980;21:91–97
  10. Nicolosi RJ, Stucchi AF, Kowala MC, et al.  Effect of dietary fat saturation and cholesterol on LDL composition and metabolism. In: In vivo studies of receptor and nonreceptor-mediated catabolism of LDL in Cebus monkeys. ed 3. Arteriosclerosis. 10:1990;p. 119–128
  11. Fernandez ML, Lin ECK, McNamara DJ. Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation. J Lipid Res. 1992;33:97–109
  12. Brousseau ME, Stucchi AF, Vespa DB, et al.  A diet enriched in monounsaturated fats decreases low density lipoprotein concentrations in cynomolgus monkeys by a different mechanism than does a diet enriched in polyunsaturated fats. J Nutr. 1993;123:2049–2058
  13. Grundy SM. Cholesterol and Atherosclerosis: Diagnosis and Treatment. Philadelphia, PA: Lippincott; 1990;
  14. Ginsberg HN. Lipoprotein physiology and its relationship to atherogenesis. Endocrinol Metab Clin North Am. 1990;19:211–228
  15. Hunt CE, Funk GM, Vidmar TJ. Dietary polyunsaturated fatty acid ratio alters hepatic LDL transport in cynomolgus macaques fed low cholesterol diets. J Nutr. 1992;122:1960–1970
  16. Linga V, Leight MA, St. Clair RW, et al.  Dietary fish oil modification of cynomolgus monkey low density lipoproteins results in decreased binding and cholesteryl ester accumulation by cultured fibroblasts. J Lipid Res. 1993;34:769–778
  17. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345–1353
  18. Markwell MAK, Haas SM, Bieber LL, et al.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 1978;87:206–210
  19. Hara H, Howard BV. Characterization of LDL binding in TR 715-19 cells. In: A high capacity, stable line for evaluating the binding of LDL to the human LDL receptor. ed 3. Atherosclerosis. 83:1990;p. 155–165
  20. Bilheimer DW, Eisenberg S, Levy RL. The metabolism of very low density lipoproteins. I. Preliminary in vitro and in vivo observations. Biochim Biophys Acta. 1972;260:212–221
  21. MacFarlane AS. Efficient trace labeling of proteins with iodine. Nature. 1958;182:53–65
  22. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509
  23. Allain CC, Poon LS, Chan CSG, et al.  Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–475
  24. Davis CG, Lehrman MA, Russell DW, et al.  Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. Cell. 1986;45:15–24
  25. Davis CG, Lehrman MA, Russell DW, et al.  The J.D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors. Cell. 1986;45:15–26
  26. Goldstein JL, Basu SK, Brown MS. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 1983;98:241–260
  27. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci. 1949;51:660–674
  28. Neville DM. Isolation of an organ specific protein antigen from cell-surface membrane of rat liver. Biochim Biophys Acta. 1968;154:540–552
  29. Matusik EJ, Reeves VB, Flanagan VP. Determination of fatty acid methyl esters. In: Elimination of tissue-derived contamination and artifacts and preparation of a support-coated acid modified polyester liquid phase. ed 3. Anal Chim Acta. 166:1984;p. 179–188
  30. Sperry WM, Brand FC. The determination of total lipids in blood serum. J Biol Chem. 1955;213:69–76
  31. Shinitzky M, Barenholz Y. Fluidity parameters of lipid regions determined by fluorescence. Biochim Biophys Acta. 1978;515:367–394
  32. Fernandez ML, McNamara DJ. Dietary fat—mediated changes in hepatic apoprotein receptor in the guinea pig: Effect of polyunsaturated, monounsaturated, and saturated fat. Metabolism. 1989;38:1094–1102
  33. Fernandez ML, Lin EC, McNamara DJ. Differential effects of saturated fatty acids on low density lipoprotein metabolism in the guinea pig. J Lipid Res. 1992;33:1833–1842
  34. Fox JC, McGill HC, Carey KD, et al.  In vivo regulation of hepatic LDL receptor mRNA in the baboon. J Biol Chem. 1987;262:7014–7020
  35. Srivastava RAK, Jiao S, Tang J, et al.  In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice. Biochim Biophys Acta. 1991;1086:29–43
  36. Hennessy LK, Osada J, Ordovas JM, et al.  Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoprotein A-I, B, and E and LDL receptor mRNA levels in Cebus monkeys. J Lipid Res. 1992;33:351–360
  37. Sorci-Thomas M, Hendricks CL, Kearns MW. HepG2 cell LDL receptor activity and the accumulation of apolipoprotein B and E in response to docosahexaenoic acid and cholesterol. J Lipid Res. 1992;33:1147–1156
  38. Lindsey S, Pronczuk A, Hayes KC. Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. J Lipid Res. 1992;33:647–658
  39. Horton JD, Cuthbert JA, Spady DK. Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels. J Clin Invest. 1993;92:743–749
  40. Dietschy JM, Woolett LA, Spady DK. The interaction of dietary cholesterol and specific fatty acids in the regulation of LDL receptor activity and plasma LDL-cholesterol concentrations. Ann NY Acad Sci. 1993;676:11–26
  41. Baudet MF, Dachet C, Lasserre M, et al.  Modification in the composition and metabolic properties of human low density and high density lipoproteins by different dietary fats. J Lipid Res. 1984;25:456–468
  42. Hannah J, Kataoka S, Yamane K, et al.  Effect of dietary fatty acids on LDL binding. Ann NY Acad Sci. 1993;683:178–182
  43. Gavigan SJP, Knight BL. Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. Biochim Biophys Acta. 1981;665:632–635
  44. Loscalzo J, Freedman J, Rudd MA, et al.  Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis. 1987;7:450–455
  45. Kuo P, Weinfeld M, Loscazo J. Effect of membrane fatty acyl composition on LDL metabolism in HepG2 hepatocytes. Biochemistry. 1990;29:6626–6632
  46. Berlin E, Bhathena SJ, Judd JT, et al.  Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. Metabolism. 1989;38:790–796
  47. Berlin E, Bhathena SJ, Kliman PG, et al.  Effect of saturation of dietary lipids on insulin receptors and membrane fluidity in rabbit erythrocytes. Nutr Rep Int. 1989;39:367–380
  48. Gould RJ, Ginsberg B, Spector A. Lipid effects on the binding properties of a reconstituted insulin receptor. J Biol Chem. 1982;257:477–484
  49. Yorek M, Leeney E, Dunlap J, et al.  Effect of fatty acid composition on insulin and IGF-1 binding in retinoblastoma cells. Invest Ophthalmol Vis Sci. 1989;30:2087–2092
  50. Field CJ, Toyomizu M, Clandinin MT. Relationship between dietary fat, adipocyte membrane composition and insulin binding in the rat. J Nutr. 1989;119:1483–1489
  51. Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res. 1985;26:1015–1035
  52. Rintoul DA, Sklar LA, Simon RD. Membrane lipid modification of Chinese hamster ovary cells. In: Thermal properties of membrane phospholipids. ed 3. JBC. 253:1978;p. 7447–7452

 Supported by National Institutes of Health Grant No. HL43660-03.

PII: 0026-0495(95)90142-6

Metabolism - Clinical and Experimental
Volume 44, Issue 11 , Pages 1428-1434 , November 1995