Metabolism - Clinical and Experimental
Volume 44, Issue 6 , Pages 699-700 , June 1995

Human hepatic macrovesicular steatosis: A noninvasive study of mitochondrial ketoisocaproic acid decarboxylation

  • François Mion

      Affiliations

    • Corresponding Author InformationAddress reprint requests to François Mion, MD, pavillon O, Hôpital E. Herriot, 69437 Lyon cedex 03, France.
    • Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France
    • Inbiomed, Lyon, France
    • Laboratoire d'Etudes et d'Analyses Cinetiques du Medicament, Lyon, France
    • ,
  • Marina Rousseau

      Affiliations

    • Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France
    • Inbiomed, Lyon, France
    • Laboratoire d'Etudes et d'Analyses Cinetiques du Medicament, Lyon, France
    • ,
  • Jean-Louis Brazier

      Affiliations

    • Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France
    • Inbiomed, Lyon, France
    • Laboratoire d'Etudes et d'Analyses Cinetiques du Medicament, Lyon, France
    • ,
  • Yves Minaire

      Affiliations

    • Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France
    • Inbiomed, Lyon, France
    • Laboratoire d'Etudes et d'Analyses Cinetiques du Medicament, Lyon, France

Received 7 September 1994 ,Accepted 29 November 1994.

References 

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  2. Lieber CS. Alcohol and the liver: Metabolism of ethanol, metabolic effects and pathogenesis of injury. Acta Med Scand. 1986;703:11–55 [Suppl]
  3. Dianzani MU. Reactions of the liver to injury: Fatty liver. In:  Farber E,  Fischer MM editor. Toxic Injury of the Liver. New York, NY: Dekker; 1979;p. 281–331
  4. Lauterburg BH, Liana D, Schwarzenbach FA, et al.  Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology. 1993;17:418–422
  5. Guilluy R, Billion-Rey F, Pachiaudi C, et al.  On-line purification and carbon-13 isotopic analysis of carbon dioxide in breath: Evaluation of on-line gas chromatography-isotope ratio mass spectrometry. Anal Chim Acta. 1992;259:193–202
  6. Schoeller DA, Klein PD, Watkins JB, et al.  13C abundances of nutrients and the effect of variations in 13C isotopic abundances of test meals formulated for 13CO2 breath tests. Am J Clin Nutr. 1980;33:2375–2385
  7. Khatra BS, Chawla RK, Sewell CW, et al.  Distribution of branched-chain alpha-keto acid dehydrogenases in primate tissues. J Clin Invest. 1977;59:558–564
  8. May M, Mancusi VJ, Aftring RP, et al.  Effects of diabetes on oxidative decarboxylation of branched-chain keto acids. Am J Physiol. 1980;239:E215–E222
  9. Redlich CA, West B, Fleming L, et al.  Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology. 1990;99:748–757
  10. Poynard T, Aubert A, Bedossa P, et al.  A simple biological index for detection of alcoholic liver disease in drinkers. Gastroenterology. 1991;100:1397–1402

PII: 0026-0495(95)90179-5

Metabolism - Clinical and Experimental
Volume 44, Issue 6 , Pages 699-700 , June 1995

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