Factors affecting lipoprotein lipase in hypertensive patients

Marotta, Teodoro; Ferrara, Liberato Aldo; Di Marino, Lucrezia; Mancini, Marcello; Annuzzi, Giovanni; Russo, Ornella; D'Orta, Gennaro; Lucarelli, Carmela; Rossi, Francesco

« Previous Next »Metabolism - Clinical and Experimental
Volume 44, Issue 6 , Pages 712-718, June 1995

Factors affecting lipoprotein lipase in hypertensive patients

Teodoro Marotta
- Address reprint requests to Teodoro Marotta, MD, PhD, Istituto di Medicina Interna e Malattie Dismetaboliche, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II,” Via Sergio Pansini 5, 80131 Napoli, Italia.
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Liberato Aldo Ferrara
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Lucrezia Di Marino
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Marcello Mancini
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Giovanni Annuzzi
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Ornella Russo
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Gennaro D'Orta
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Carmela Lucarelli
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy
Francesco Rossi
- Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy
- Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy

Received 21 July 1993; accepted 28 October 1994.

Abstract

Arterial hypertension is frequently associated with serum lipid abnormalities. Lipid metabolism can also be affected by antihypertensive treatment, possibly via an interference with lipoprotein lipase (LPL) activity. The aims of this study were to investigate the metabolic and hemodynamic factors that can interfere with plasma postheparin LPL activity in a sample of 13 patients with mild, uncomplicated arterial hypertension. The effects of vasodilator administration (prazosin and hydralazine) alone or in combination with a β-blocker (propranolol) were also studied. A direct correlation between serum insulin levels and LPL activity was found during placebo treatment. This was confirmed by multiple regression analysis, which also showed a positive correlation of LPL activity with aortic flow velocity and plasma adrenaline (F significance = 0.0007, R² = .905). Serum insulin was also directly correlated with cholesterol in high-density lipoproteins (HDLs) and in the HDL₂ subfraction. A significant decrease in LPL activity was observed during the addition of propranolol to vasodilators as compared with vasodilators alone. A positive correlation was found between LPL and adrenaline changes induced by the combined treatment. These data suggest that LPL may play a role in the pathophysiologic connections between insulin action, the adrenergic nervous system (ANS), and lipid metabolism.

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