Metabolism - Clinical and Experimental
Volume 44 , Pages 50-57 , October 1995

Nutritional regulation of insulin-like growth factor-I

  • Jean-Marie Ketelslegers

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Jean-Marie Ketelslegers, MD, PhD, Unité de Diabétologie et Nutrition, Université Catholique de Louvain, Tour Claude Bernard, UCL15474, Avenue Hippocrate 54, B-1200 Bruxelles, Belgium.
    • Unit of Diabetes and Nutrition, Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    • Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
  • ,
  • Dominique Maiter

      Affiliations

    • Unit of Diabetes and Nutrition, Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    • Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
  • ,
  • Marc Maes

      Affiliations

    • Unit of Diabetes and Nutrition, Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    • Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
  • ,
  • Louis E. Underwood

      Affiliations

    • Unit of Diabetes and Nutrition, Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    • Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
  • ,
  • Jean-Paul Thissen

      Affiliations

    • Unit of Diabetes and Nutrition, Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    • Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA

References 

  1. Baumann G. Growth hormone heterogeneity: Genes, isohormones, variants and binding proteins. Endocr Rev. 1991;12:424–449
  2. Sara VR, Hall K. Insulin-like growth factors and their binding proteins. Physiol Rev. 1990;70:591–614
  3. Daughaday WH, Rotwein P. Insulin-like growth factors I and II. In: Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. ed 2. Endocr Rev. 10:1989;p. 68–91
  4. Humbel RE. Insulin-like growth factors I and II. Eur J Biochem. 1990;190:445–462
  5. Rechler MM, Nissley SP. Insulin-like growth factors. In: ed 2.  Sporn MB,  Roberts AB editor. Peptides Growth Factors and Their Receptors. vol 1:Berlin, Germany: Springer-Verlag; 1990;p. 263–367
  6. D'Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of somatomedin-C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. In: ed 2. Proc Natl Acad Sci USA. 81:1984;p. 935–939
  7. Han VKM, D'Ercole AJ, Lund PK. Cellular location of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science. 1987;236:193–197
  8. McConaghey P, Sledge CB. Production of “sulphation factor” by the perfused liver. Nature. 1970;225:1249–1250
  9. Schwander JC, Hauri C, Zapf J, et al.  Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status. Endocrinology. 1983;113:297–305
  10. Miller LL, Schalch DS, Draznin B. Role of the liver in regulating somatomedin activity: Effects of streptozotocin diabetes and starvation on the synthesis and release of insulin-like growth factor and its carrier protein by the isolated perfused rat liver. Endocrinology. 1981;108:1265–1271
  11. Furlanetto RW, Underwood LE, Van Wyk JJ, et al.  Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest. 1977;60:648–657
  12. Rechler MM, Nissley SP. The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol. 1985;47:425–442
  13. Van Wyk JJ. The somatomedins: Biologic actions and physiologic control mechanisms. In:  Li CH editors. Hormonal Proteins and Peptides. New York, NY: Academic; 1984;p. 81–125
  14. Underwood LE, D'Ercole AJ, Clemmons DR, et al.  Paracrine functions of somatomedins. Clin Endocrinol Metab. 1986;15:59–77
  15. Holly JMP, Wass JAH. Insulin-like growth factors: Autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments. J Endocrinol. 1989;122:611–618
  16. Salmon WD, Daughaday WH. A hormonally-controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957;49:825–836
  17. Shimasaki S, Ling N. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1,-2,-3,-4,-5 and -6). Prog Growth Factor Res. 1992;3:243–266
  18. Martin JL, Baxter RC. Insulin-like growth factor binding protein-3: Biochemistry and physiology. Growth Regul. 1992;2:88–99
  19. Baxter RC, Martin JL, Beniac VA. High molecular weight insulin-like growth factor binding protein complex: Purification and properties of the acid-labile subunit from human serum. J Biol Chem. 1989;264:11843–11848
  20. Baxter RC, Martin JL. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: Determination by reconstitution and affinity-labelling. In: ed 2. Proc Natl Acad Sci USA. 86:1989;p. 6898–6902
  21. Clemmons DR. Insulin-like growth factors binding proteins. In:  LeRoith D editors. Insulin-Like Growth Factors: Molecular and Cellular Aspects. Boca Raton, FL: CRC; 1991;p. 151–179
  22. Copeland KC, Underwood LE, Van Wyk JJ. Induction of immunoreactive somatomedin-C in human serum by growth hormone: Dose response relationships and effect on chromatographic profiles. J Clin Endocrinol Metab. 1980;50:690–697
  23. Winter RJ, Phillips LS, Green OC, et al.  Somatomedin activity in the Mauriac syndrome. J Pediatr. 1980;97:598–600
  24. Maes M, Ketelslegers JM, Underwood LE. Low plasma somatomedin-C in streptozocin-induced diabetes mellitus: Correlation with changes in somatogenic and lactogenic liver binding sites. Diabetes. 1983;32:1060–1064
  25. Maes M, Underwood LE, Ketelslegers JM. Low serum somatomedin-C in insulin-dependent diabetes: Evidence for a post-receptor mechanism. Endocrinology. 1986;118:377–382
  26. Grant DB, Hambley J, Becker D, et al.  Reduced sulphation factor in undernourished children. Arch Dis Child. 1973;48:596–600
  27. Hintz RL, Suskind R, Amatayakul K, et al.  Plasma somatomedin and growth hormone values in children with protein calorie malnutrition. J Pediatr. 1978;92:153–156
  28. Smith IF, Latham MC, Azabuike JA, et al.  Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition. In: ed 2. Proc Soc Exp Biol Med. 167:1981;p. 607–611
  29. Soliman AT, Hassan AE, Aref MK, et al.  Serum insulin-like growth factor I and II concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation. Pediatr Res. 1986;20:1122–1130
  30. Rappaport R, Prevot C, Czernichow P. Somatomedin activity and growth hormone secretion. I. Changes related to body weight in anorexia nervosa. Acta Paediatr Scand. 1980;69:37–41
  31. Counts DR, Gwirtsman H, Carlsson LM, et al.  The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab. 1992;75:762–767
  32. Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology. 1986;91:830–836
  33. Salbe AD, Kotler DP, Wang J, et al.  Predictive value of IGF-I concentrations in HIV-infected patients. Clin Res. 1991;39:385A; (abstr)
  34. Clemmons DR, Klibanski A, Underwood LE, et al.  Reduction of plasma immunoreactive somatomedin-C during fasting in humans. J Clin Endocrinol Metab. 1981;53:1247–1250
  35. Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest. 1983;71:175–182
  36. Isley WL, Underwood LE, Clemmons DR. Changes in plasma somatomedin-C in response to ingestion of diets with variable protein and energy content. JPEN. 1984;8:407–411
  37. Clemmons DR, Seek M, Underwood LE. Supplementary essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting. Metabolism. 1985;34:391–395
  38. Clemmons DR, Underwood LE, Dickerson RN, et al.  Use of somatomedin-C/insulin-like growth factor I measurements to monitor nutritional repletion in malnourished patients. Am J Clin Nutr. 1985;4:191–198
  39. Unterman TG, Vazquez RM, Sla AJ, et al.  Nutrition and somatomedia. XII. Usefulness of somatomedin-C in nutritional assessment. Am J Med. 1985;78:228–234
  40. Colletti RB, Copeland KC, Devlin JT, et al.  Effect of obesity on plasma insulin-like growth factor-I in cancer patients. Int J Obes. 1991;15:523–527
  41. Wilson DM, Killen JD, Hammer LD, et al.  Insulin-like growth factor-I as a reflection of body composition, nutrition and puberty in sixth and seventh grade girls. J Clin Endocrinol Metab. 1991;73:907–912
  42. Sullivan DH, Carter WJ. Insulin-like growth factor I as an indicator of protein-energy undernutrition among metabolically stable hospitalized elderly. J Am Coll Nutr. 1994;13:184–191
  43. Forbes GB, Brown MR, Welle SL, et al.  Hormonal response to overfeeding. Am J Clin Nutr. 1989;49:608–611
  44. Marin P, Kvist H, Lindstedt G, et al.  Low concentrations of insulin-like growth factor-I in abdominal obesity. Int J Obes. 1993;17:83–89
  45. Rasmussen MH, Frystyk J, Andersen T, et al.  The impact of obesity, fat distribution and energy restriction on insulin-like growth factor-I (IGF-I), IGF-binding protein-3, insulin, and growth hormone. Metabolism. 1994;43:315–319
  46. Ho KY, Veldhuis JD, Johnson ML, et al.  Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988;81:968–975
  47. Merimée TJ, Zapf J, Froesch ER. Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab. 1982;55:999–1002
  48. Phillips LS, Young HS. Nutrition and somatomedin. I. Effect of fasting and refeeding on serum somatomedin activity and cartilage growth activity in rats. Endocrinology. 1976;99:304–314
  49. Maes M, Underwood LE, Ketelslegers JM. Plasma somatomedin-C in fasted and refed rats: Close relationship with changes in liver somatogenic, but not lactogenic, binding sites. J Endocrinol. 1983;97:243–252
  50. Maes M, Underwood LE, Ketelslegers JM. Low serum somatomedin-C in protein deficiency: Relationship with changes in liver somatogenic and lactogenic binding sites. Mol Cell Endocrinol. 1984;37:301–309
  51. Baxter RC, Bryson JM, Turtle JR. The effect of fasting on liver receptors for prolactin and growth hormone. Metabolism. 1981;30:1086–1090
  52. Postel-Vinay MC, Cohen-Tough E, Charrier J. Growth hormone receptors in rat liver membranes: Effect of fasting and refeeding and correlation with plasma somatomedin activity. Mol Cell Endocrinol. 1982;28:657–669
  53. Straus DS, Takemoto CD. Effect of fasting on insulin-like growth factor-I (IGF-I) and growth hormone receptor mRNA levels and IGF-I gene transcription in rat liver. Mol Endocrinol. 1990;4:91–100
  54. Maiter D, Maes M, Underwood LE, et al.  Early changes in serum concentrations of somatomedin-C induced by dietary protein deprivation in rats: Contributions of growth hormone receptor and post-receptor defects. J Endocrinol. 1988;118:113–120
  55. Fliesen T, Maiter D, Gerard G, et al.  Reduction of serum insulin-like growth factor-I by dietary protein restriction is age dependent. Pediatr Res. 1989;26:415–419
  56. Thissen JP, Triest S, Underwood LE, et al.  Divergent responses of serum insulin-like growth factor-I and liver growth hormone (GH) receptors to exogenous GH in protein-restricted rats. Endocrinology. 1990;126:908–913
  57. Maes M, Amand Y, Underwood LE, et al.  Decreased serum insulin-like growth factor I response to growth hormone in hypophysectomized rats fed a low protein diet: Evidence for a postreceptor defect. Acta Endocrinol (Copenh). 1988;117:320–326
  58. Thissen JP, Triest S, Maes M, et al.  The decreased plasma concentration of insulin-like growth factor-I in protein-restricted rats in not due to decreased numbers of growth hormone receptors on isolated hepatocytes. J Endocrinol. 1990;124:159–165
  59. Maiter D, Fliesen T, Underwood LE, et al.  Dietary protein restriction decreases insulin-like growth factor I independent of insulin and liver growth hormone binding. Endocrinology. 1989;124:2604–2611
  60. Thissen JP, Pucilowska JB, Underwood LE. Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture. Endocrinology. 1994;134:1570–1576
  61. Phillips LS, Goldstein S, Pao CI. Nutrition and somatomedin. XXVI. Molecular regulation of IGF-I by insulin in cultured rat hepatocytes. Diabetes. 1991;40:1525–1530
  62. Harp JB, Goldstein S, Phillips LS. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes. Diabetes. 1991;40:95–101
  63. Thissen JP, Triest S, Moats-Staats BM, et al.  Evidence that pretranslational and translational defects decrease serum insulinlike growth factor-I concentrations during dietary protein restriction. Endocrinology. 1991;129:429–435
  64. Emler CA, Schalch DS. Nutritionally-induced changes in hepatic insulin-like growth factor-I (IGF-I) gene expression in rats. Endocrinology. 1987;120:832–838
  65. Moats-Staats BM, Brady JL, Underwood LE, et al.  Dietary protein restriction in artificially-reared neonatal rats causes a reduction of insulin-like growth factor I (IGF-I) gene expression. Endocrinology. 1989;125:2368–2374
  66. Bornfeldt KE, Arnqvist HJ, Enberg B, et al.  Regulation of insulin-like growth factor-I and growth hormone receptor gene expression by diabetes and nutritional state in rat tissues. J Endocrinol. 1989;122:651–656
  67. VandeHaar M, Moats-Staats BM, Davenport ML, et al.  Reduced serum concentrations of insulin-like growth factor-I (IGF-I) in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle. J Endocrinol. 1991;103:305–312
  68. Lowe WL, Adamo M, Werner H, et al.  Regulation by fasting of rat insulin-like growth factor I and its receptor. In: Effects on gene expression and binding. ed 2. J Clin Invest. 84:1989;p. 619–626
  69. Thissen JP, Underwood LE. Translational status of the insulin-like growth factor-I mrna in liver of protein-restricted rats. J Endocrinol. 1992;132:141–147
  70. Thissen JP, Davenport ML, Pucilowska JB, et al.  Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats. Am J Physiol. 1992;262:E406–E411
  71. Thissen JP, Underwood LE, Maiter D, et al.  Failure of insulin-like growth factor-I (IGF-I) infusion to promote growth in protein-restricted rats despite normalization of serum IGF-I concentrations. Endocrinology. 1991;128:885–890
  72. Thissen JP, Underwood LE, Vanderijst JF, et al.  Anabolic effects of combined exogenous GH/IGF-I in protein restricted rats. Growth Regul. 1994;89; (abstr 1162)
  73. Philipps AF, Persson B, Hall K, et al.  The effects of biosynthetic insulin-like growth factor-I supplementation on somatic growth, maturation, and erythropoiesis in the neonatal rat. Pediatr Res. 1988;23:298–305
  74. O'Sullivan U, Gluckmann PD, Breier BH, et al.  Insulin-like growth factor-I (IGF-I) in mice reduces weight loss during starvation. Endocrinology. 1989;125:2793–2794
  75. Asakawa K, Hizuka N, Takano K, et al.  Effects of insulin-like growth factor-I or human growth hormone in fasted rats. Growth Regul. 1992;2:40–44

 Supported by grants from the Fonds National de la Recherche Scientifique (3.4538.80, 3.4544.87, 3.4559.93, and 1.5.333.86F), Brussels, Belgium, National Institutes of Health (NIH) Grants No. HD26871 and HD08299, NIH Training Grant No. AM07129, and a NIH Fogarty International Fellowship (TW04384).

PII: 0026-0495(95)90221-X

Metabolism - Clinical and Experimental
Volume 44 , Pages 50-57 , October 1995