Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 825-832 , July 1995

Altered lipid composition and differential changes in activities of membrane-bound enzymes of erythrocytes in hepatic cirrhosis

Received 9 December 1993 ,Accepted 17 October 1994.

References 

  1. Simon JB. Red cell lipids in liver disease. In: Relationship to serum lipids and to lecithin-cholesterol acyltransferase. ed 12. J Lab Clin Med. 77:1971;p. 891–900
  2. Kawata S, Chitranukroh A, Owen JS, et al.  Membrane lipid changes in erythrocytes, liver and kidney in acute and chronic experimental liver disease in rats. Biochim Biophys Acta. 1987;896:26–34
  3. Owen JS, Bruckdorfer KR, Day RC, et al.  Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease. J Lipid Res. 1982;23:124–132
  4. Owen JS, Hutton RA, Day RC, et al.  Platelet lipid composition and platelet aggregation in human liver disease. J Lipid Res. 1981;22:423–430
  5. Cooper RA, Diloy-Puray M, Lando P. An analysis of lipoproteins, bile acids, and red cell membranes associated with target cells and spur cells in patients with liver disease. J Clin Invest. 1972;51:3182–3192
  6. Owen JS. Extrahepatic cell membrane lipid abnormalities and cellular dysfunction in liver disease. Drugs. 1990;40(suppl 3):73–83
  7. Cooper RA. Abnormalities of cell-membrane fluidity in the pathogenesis of disease. N Engl J Med. 1977;297:371–377
  8. Simon JB. Red cell lipids in liver disease: Relationship to serum lipids and to lecithin-cholesterol acyltransferase. J Lab Clin Med. 1971;77:891–900
  9. Seidel D. Lipoproteins in liver disease. J Clin Chem Clin Biochem. 1987;25:541–551
  10. Imai Y, Scoble JE, McIntyre N, et al.  Increased Na+-dependent d-glucose transport and altered lipid composition in renal cortical brush-border membrane vesicles from bile-duct ligated rats. J Lipid Res. 1992;33:473–483
  11. Molitoris BA. Membrane fluidity. In: Measurement and relation to solute transport. ed 12. Semin Nephrol. 7:1987;p. 61–71
  12. Jackson PA, Morgan DB. The relation between membrane cholesterol and phospholipid and sodium efflux in erythrocytes from healthy subjects and patients with cholestasis. Clin Sci. 1982;62:104–107
  13. Hanahan DJ, Ekholm JE. The preparation of red cell ghosts (membranes). In:  Fleischer S,  Packer L editor. Methods in Enzymology. New York, NY: Academic; 1974;p. 168–172
  14. Lowry OH, Rosebrough NJ, Farr AL, et al.  Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911–917
  16. Folch J, Lees M, Stanley SGH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–503
  17. Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem. 1959;234:466–468
  18. Chen C, Albers JJ. Characterization of proteoliposomes containing apoprotein A-1: A new substrate for the measurement of lecithin:cholesterol acyltransferase activity. J Lipid Res. 1982;23:680–691
  19. Shinitzky M, Inbar M. Microviscosity parameters and protein mobility in biological membranes. Biochim Biophys Acta. 1976;433:133–149
  20. Jenkins WT, Marshall MM. A modified direct phosphate for studying ATPases. Anal Biochem. 1984;141:155–160
  21. Ellman GL, Courtney KD, Andres V, et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95
  22. Pelikanova T, Kohout M, Valek J, et al.  Fatty acid composition of serum lipids and erythrocyte membranes in type II (non-insulin-dependent) diabetic men. Metabolism. 1991;40:175–180
  23. Gonzalez J, Periago JL, Cabre E, et al.  Malnutrition-related polyunsaturated fatty acid changes in plasma lipid fractions of cirrhotic patients. Metabolism. 1992;41:954–960
  24. Borochov H, Zahler P, Wilbrandt W, et al.  The effect of phosphatidylcholine to sphingomyelin mole ratio on the dynamic properties of sheep erythrocyte membrane. Biochim Biophys Acta. 1977;470:382–388
  25. Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res. 1985;26:1015–1035
  26. Gjone E, Norum KR. Plasma lecithin-cholesterol acyltransferase and erythrocyte lipids in liver disease. Acta Med Scand. 1970;187:153–161
  27. Horton RC, Owen JS. LCAT activity as a prognostic liver function test. Lancet. 1990;28:249–250
  28. Giraud F, Claret M, Garay R. Interactions of cholesterol with the Na pump in red blood cells. Nature. 1976;264:646–648
  29. Incerpi S, Baldini P, Luly P. Cholesterol modulation in vitro of plasma membrane-bound enzymes in human erythrocytes. Cell Mol Biol. 1983;29:285–289
  30. Testa I, Rabini RA, Fumelli P, et al.  Abnormal membrane fluidity and acetylcholinesterase activity in erythrocytes from insulin-dependent diabetic patients. J Clin Endocrinol Metab. 1988;67:1129–1133
  31. Owen JS, McIntyre N. Erythrocyte lipid composition and sodium transport in human liver disease. Biochim Biophys Acta. 1978;510:168–176
  32. Morrot G, Zachowski A, Devaux PF. Partial purification and characterization of the human erythrocyte Mg2+-ATPase: A candidate aminophospholipid translocase. FEBS Lett. 1990;266:29–32
  33. Schrier SL. Human erythrocyte membrane enzymes: Current status and clinical correlates. Blood. 1977;50:227–237
  34. Low MG. The glycosyl-phosphatidylinositol anchor of membrane proteins. Biochim Biophys Acta. 1989;988:427–454
  35. Cross GAM. Glycolipid anchoring of plasma membrane proteins. Annu Rev Cell Biol. 1990;6:1–39
  36. Brasitus TA, Dahiya R, Dudeja PK, et al.  Cholesterol modulates alkaline phosphatase activity of rat intestinal microvillus membranes. J Biol Chem. 1988;263:8592–8597

PII: 0026-0495(95)90233-3

Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 825-832 , July 1995

Article Tools