Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 833-840 , July 1995

Influence of short-term submaximal exercise on parameters of glucose assimilation analyzed with the minimal model

  • J.F. Brun

      Affiliations

    • Corresponding Author InformationAddress reprint requests to J.F. Brun, MD, PhD, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, 34295 Montpellier, Cédex 5, France.
    • Prediabetes Unit, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, Montpellier, France
    • Département de Physiologie, Institut de Biologie, Faculté de Medecine, Montpellier, France
  • ,
  • R. Guintrand-Hugret

      Affiliations

    • Prediabetes Unit, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, Montpellier, France
    • Département de Physiologie, Institut de Biologie, Faculté de Medecine, Montpellier, France
  • ,
  • C. Boegner

      Affiliations

    • Prediabetes Unit, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, Montpellier, France
    • Département de Physiologie, Institut de Biologie, Faculté de Medecine, Montpellier, France
  • ,
  • O. Bouix

      Affiliations

    • Prediabetes Unit, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, Montpellier, France
    • Département de Physiologie, Institut de Biologie, Faculté de Medecine, Montpellier, France
  • ,
  • A. Orsetti

      Affiliations

    • Prediabetes Unit, Service d'Exploration Physiologique des Hormones, Lapeyronie Hospital, Montpellier, France
    • Département de Physiologie, Institut de Biologie, Faculté de Medecine, Montpellier, France

Received 9 December 1993 ,Accepted 21 October 1994.

References 

  1. Conard V, Franckson JRM. Influence de l'effort musculaire sur l'assimilation glucidique chez l'homme normal. C R Soc Biol. 1957;51:2228–2230
  2. Ivy JL. The insulin-like effect of muscle contraction. Exerc Sport Sci Rev. 1987;15:29–51
  3. Ploug T, Galbo H, Richter EA. Increased muscle glucose uptake during contractions: No need for insulin. Am J Physiol. 1984;247:E726–E731
  4. Wallberg-Henriksson HS, Constable H, Young DA, et al.  Glucose transport into rat skeletal muscle: Interaction between exercise and insulin. J Appl Physiol. 1988;65:909–913
  5. Gulve EA, Cartee GD, Zierath JR, et al.  Reversal of enhanced muscle glucose transport after exercise: Roles of insulin and glucose. Am J Physiol. 1990;259:E685–E691
  6. Douen AG, Ramlal T, Rastogi S, et al.  Exercise induces recruitment of the insulin-responsive glucose transporter. In: Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. ed 12. J Biol Chem. 265:1990;p. 13427–13430
  7. Klip A, Marette A. Acute and chronic signals controlling glucose transport in skeletal muscle. J Cell Biochem. 1992;48:51–60
  8. Barnard RJ, Youngren JF. Regulation of glucose transport in skeletal muscle. FASEB J. 1992;6:3238–3244
  9. Annunzi G, Riccardi G, Capaldo B, et al.  Increased insulin-stimulated glucose uptake by exercised human muscles one day after prolonged physical exercise. Eur J Clin Invest. 1991;21:6–12
  10. Baron AD, Brechtel G, Wallace P, et al.  Rates and tissue sites of non-insulin mediated glucose uptake in humans. Am J Physiol. 1988;255:E769–E774
  11. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev. 1985;6:45–86
  12. Bergman RN, Ider YZ, Bowden CR, et al.  Quantitative estimation of insulin sensitivity. Am J Physiol. 1979;236:E667–E677
  13. Yang YJ, Youn JA, Bergman RN. Modified protocols to improve insulin sensitivity estimation using the minimal model. Am J Physiol. 1987;253:E595–E602
  14. Kahn SE, Bergman RN, Schwartz MW, et al.  Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol. 1992;262:E518–E523
  15. Wahlund H. Determination of physical working capacity. Acta Med Scand. 1948;215:1–78
  16. Bouix O, Brun JF, Orsetti A. The magnitude, the kinetics and the metabolic efficiency of first-phase insulin response to intravenous glucose are related. Horm Metab Res. 1993;25:312–316
  17. Steil GM, Bergman RM. Reduced sampling for the minimal model estimate of insulin sensitivity from the modified and standard frequently sampled IVGTT. Diabetes. 1991;40(suppl 1):38A; abstr
  18. Conard V, Franckson JRM, Bastenie PA, et al.  Etude critique du triangle d'hyperglycemie intraveineux chez l'homme normal et détermination d'un coefficient d'assimilation glucidique. Arch Int Pharmacodyn. 1953;93:277–292
  19. Brun JF, Guintrand-Hugret R, Forts C, et al: Effects of oral zinc gluconate on glucose effectiveness and insulin sensitivity in humans. Biol Trace Elem Res (in press)
  20. Brun JF, Boegner C, Orsetti A. Le minimal model: un nouvel outil pour l'étude des hypoglycémies du sportif. Sci Sports. 1994;9:47–49
  21. Bogardus C, Thuillez P, Ravussin E, et al.  Effect of muscle glycogen depletion on in vivo insulin action in man. J Clin Invest. 1983;72:1605–1610
  22. Bergman RN. Toward physiological understanding of glucose tolerance. In: Minimal model approach. ed 12. Diabetes. 38:1989;p. 1512–1527
  23. Finegood DT, Pacini G, Bergman RN. The insulin sensitivity index. In: Correlation in dogs between values determined from the intravenous glucose tolerance test and the euglycemic glucose clamp. ed 12. Diabetes. 33:1984;p. 362–368
  24. Bergman RN, Prager R, Volund A, et al.  Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 1987;79:790–800
  25. Ferrari P, Alleman Y, Shaw S, et al.  Reproducibility of insulin sensitivity measured by the minimal model method. Diabetologia. 1991;34:527–530
  26. Welch S, Gebhart SSP, Bergman RN, et al.  Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab. 1990;71:1508–1518
  27. Ward GM, Weber KM, Walters IM, et al.  A modified minimal model analysis of insulin sensitivity and glucose-mediated glucose disposal in insulin-dependent diabetes. Metabolism. 1991;40:4–9
  28. Cutfield WS, Bergman RN, Menon RK, et al.  The modified minimal model: Application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab. 1990;70:1644–1650
  29. Kahn SE, Larson VG, Beard JC, et al.  Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am J Physiol. 1990;258:E937–E943
  30. Pestell RG, Ward GM, Galvin P, et al.  Impaired glucose tolerance after endurance exercise is associated with reduced insulin secretion rather than altered insulin sensitivity. Metabolism. 1993;42:277–282
  31. Prigeon RL, Porte D. Effect of acute exercise on insulin sensitivity and glucose effectiveness. Diabetes. 1993;42(suppl 1):203A; abstr
  32. Tokuyama K, Higaki Y, Fujitani J, et al.  Intravenous glucose tolerance test-derived glucose effectiveness in physically trained humans. Am J Physiol. 1993;265:E298–E303
  33. King DS, Dalsky GP, Clutter WE, et al.  Effects of exercise and lack of exercise on insulin sensitivity and responsiveness. J Appl Physiol. 1988;54:1942–1946
  34. Mikines KJ, Sonne B, Farrel PA, et al.  Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol. 1988;254:E248–E259
  35. Dorchy H, Niset G, Ooms H, et al.  Study of the coefficient of glucose assimilation during muscular exercise in diabetic adolescents deprived of insulin. Diabete Metab. 1977;3:31–34
  36. Ader M, Pacini G, Yang YJ, et al.  Importance of glucose per se to intravenous glucose tolerance. In: Comparison of the minimal model prediction with direct measurements. ed 12. Diabetes. 34:1985;p. 1092–1103
  37. Kahn SE, Klaff LJ, Schwartz MW, et al.  Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J Clin Endocrinol Metab. 1990;71:994–1002
  38. Finegood DT, Bergman RN, Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. In: Comparison of unlabeled and labeled exogenous glucose infusates. ed 12. Diabetes. 36:1987;p. 914–924
  39. Hother-Nielsen O, Mengel A, Moller J, et al.  Assessment of glucose turnover rates in euglycaemic clamp studies using primed-constant [3-3H]-glucose infusion and labelled or unlabelled glucose infusates. Diabetic Med. 1992;9:840–849
  40. Beck-Nielsen H, Hother-Nielsen O, Vaag A, et al.  Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: The role of skeletal muscle glucose uptake and hepatic glucose production in the development of hyperglycaemia. In: A critical comment. ed 12. Diabetologia. 37:1994;p. 217–221
  41. Finegood DT, Tzur D. Variations in whole body glucose effectiveness are dependent on variations of the sensitivity of glucose disposal and not glucose production to glucose. Diabetes. 1994;43:68A; (abstr)
  42. Pacini G, Cobelli C. Development in minimal modeling of IVGTT: The measurement of glucose production. In:  Carson ER,  Kneppo P,  Krekule I editor. Advances in Biomedical Measurement. New York, NY: Plenum; 1988;
  43. Galbo H. Hormonal and Metabolic Adaptation to Exercise. Stuttgart, Germany: Georg Thieme Verlag; 1983;

PII: 0026-0495(95)90234-1

Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 833-840 , July 1995