Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 855-864 , July 1995

Carbohydrate-fat exchange and regulation of hepatic cholesterol and plasma lipoprotein metabolism in the guinea pig

Received 4 February 1994 ,Accepted 24 October 1994.

References 

  1. Stamler J, Wentforth D, Neaten JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?. In: Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). ed 12. JAMA. 256:1986;p. 2823–2828
  2. McNamara DJ. Dietary fatty acids, lipoproteins and cardiovascular disease. Adv Food Nutr Res. 1992;36:253–361
  3. Grundy SM. Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med. 1986;314:745–748
  4. Grundy SM, Florentin L, Nix D, et al.  Comparison of monounsaturated fatty acids and carbohydrates for reducing raised levels of plasma cholesterol in man. Am J Clin Nutr. 1987;47:965–969
  5. Garg A, Grundy SM, Unger RH. Comparison of effects of high and low carbohydrate diets on plasma lipoproteins and insulin sensitivity in patients with mild NIDDM. Diabetes. 1992;41:1278–1285
  6. Nestel PJ, Reardon M, Fidge NH. Sucrose-induced changes in VLDL- and LDL-B apoprotein removal rates. Metabolism. 1979;28:531–535
  7. Brinton EA, Eisenberg S, Breslow JL. A low fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest. 1990;85:144–151
  8. Zimmermann J, Eisenberg S, Kauffman NA, et al.  Effect of moderate isocaloric modifications of dietary carbohydrate on high-density lipoprotein composition and apolipoprotein A-I turnover in humans. Isr J Med Sci. 1986;22:95–104
  9. Gingsberg HN, Le N-A, Melish J, et al.  Effect of a high carbohydrate diet on apoprotein-B catabolism in man. Metabolism. 1980;30:347–353
  10. Abbott WGH, Swinburn B, Ruotolo G, et al.  Effect of a high-carbohydrate, low-saturated-fat diet on apolipoprotein B and triglyceride metabolism in Pima Indians. Metabolism. 1990;86:642–650
  11. Huff MW, Nestel Paul J. Metabolism of apolipoproteins CII, CIII1, CIII2 and VLDL-B in human subjects consuming high carbohydrate diets. Metabolism. 1982;31:493–498
  12. Keidar S, Goldberg AC, Cook K, et al.  High carbohydrate fat-free diet modulates epitope expression of LDL-apoB-100 and interaction of LDL with human fibroblasts. J Lipid Res. 1989;30:1133–1331
  13. Ha YC, Barter PA. Differences in plasma cholesteryl ester transfer activity in sixteen vertebrae species. Comp Biochem Physiol. 1982;71:265–269
  14. Angelin B, Olivecrona H, Reihner E, et al.  Hepatic cholesterol metabolism in estrogen-treated man. Gastroenterology. 1992;103:1657–1663
  15. Fernandez ML, Lin ECK, McNamara DJ. Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation. J Lipid Res. 1992;33:97–109
  16. Lin ECK, Fernandez ML, McNamara DJ. Dietary fat type and cholesterol quantity interact to affect cholesterol metabolism in guinea pigs. J Nutr. 1992;122:2019–2029
  17. Fernandez ML, Sun D-M, Tosca M, et al.  Citrus pectin and cholesterol interact to regulate hepatic cholesterol homeostasis and lipoprotein metabolism. Am J Clin Nutr. 1994;59:867–878
  18. Allain CC, Poon LC, Chan CGS, et al.  Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–475
  19. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476–482
  20. Carr T, Andresen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem. 1993;26:39–42
  21. Fernandez ML, McNamara DJ. Regulation of cholesterol and lipoprotein metabolism in guinea pigs mediated by dietary fat quality and quantity. J Nutr. 1991;121:934–943
  22. Markwell MAK, Haas SM, Bieber LL, et al.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 1978;87:206–210
  23. Chapman JM, Mills GL, Ledford JF. The distribution and partial characterization of the serum apolipoproteins in the guinea pig. Biochem J. 1975;149:423–436
  24. Fernandez ML, McNamara DJ. High density lipoprotein binding to guinea pig hepatic membranes. In: Comparison of guinea pig and human ligands. ed 12. Biochim Biophys Acta. 1042:1990;p. 142–145
  25. Goldstein JL, Basu SK, Brown MS. Receptor-mediated endocytosis of low density lipoprotein in cultured cells. Methods Enzymol. 1983;98:241–260
  26. Keightley DD, Fisher RJ, Cressie NAC. Properties and interpretation of the Woolf and Scatchard plots in analyzing data from steroid receptor assays. J Steroid Biochem. 1983;19:1407–1412
  27. Fernandez ML, McNamara DJ. Dietary fat saturation and chain length modulate guinea pig hepatic cholesterol metabolism. J Nutr. 1994;124:331–339
  28. Smith JL, de Jersey J, Pillay SP, et al.  Hepatic acyl-CoA: cholesterol acyltransferase. In: Development of a standard assay and determination in patients with cholesterol gallstones. ed 12. Clin Chim Acta. 158:1986;p. 271–282
  29. Committee on Animal Nutrition, National Research Council . Nutrient requirements of the guinea pig. In: Nutrient Requirements of Laboratory Animals. Washington, DC: National Academy of Sciences; 1978;p. 59–67
  30. Reid ME. Production and counteraction of a fatty acid deficiency in the guinea pig. In: ed 12. Proc Soc Exp Biol. 13:1954;p. 708–709
  31. Fernandez ML, Lin ECK, McNamara DJ. Differential effects of saturated fatty acids on low density lipoprotein metabolism in the guinea pig. J Lipid Res. 1992;33:1833–1842
  32. Fernandez ML, Abdel-Fattah G, McNamara DJ. Dietary fat saturation modifies the metabolism of LDL subtractions in guinea pigs. Arterioscler Thromb. 1993;13:1418–1428
  33. Abdel-Fattah G, Fernandez ML, McNamara DJ. Dietary fat saturation effects on hepatic VLDL secretion rates in guinea pigs. FASEB J. 1993;6:A868; (abstr)
  34. Carr T, Parks JS, Rudel LL. Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis. Arterioscler Thromb. 1992;12:1274–1283
  35. Ginsberg HN. Lipoprotein physiology and its relationship to atherogenesis. Endocrinol Metab Clin North Am. 1990;19:211–228
  36. McKnight GL, Reasoner J, Gilber T, et al.  Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. J Biol Chem. 1992;267:12131–12141
  37. Fernandez ML, McNamara DJ. Characterization of high density lipoprotein binding to guinea pig hepatic membranes: Effects of dietary fat quality and cholesterol. Metabolism. 1991;40:127–134
  38. Fernandez ML, Lin ECK, McNamara DJ. Dietary saturated fat composition modifies high density lipoprotein binding to guinea pig hepatic membranes. Nutr Res. 1994;5:753–764
  39. Coiffier E, Paris R, Lecerf J. Effects of dietary saturated and polyunsaturated fat on lipoprotein lipase and hepatic triglyceride lipase activity. Comp Biochem Physiol. 1987;88B:187–192
  40. Eisenberg S, Gavish D, Oschry Y, et al.  Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. J Clin Invest. 1984;74:470–482
  41. Daumerie CM, Woollett LA, Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. In: ed 12. Proc Natl Acad Sci USA. 80:1992;p. 10797–10801
  42. Zhao SP, Verhoeven MH, Vink J, et al.  Relationship between apolipoprotein E and low density lipoprotein particle size. Atherosclerosis. 1993;102:147–154

☆ Supported by a Grant-in-Aid from the American Heart Association, Arizona Affiliate, Tempe, AZ.

PII: 0026-0495(95)90237-6

Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 855-864 , July 1995

Article Tools