Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 869-875 , July 1995

Relationship between insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus: β-cell function, islet cell antibody, and haptoglobin in parents of IDDM patients

  • Hiroshi Kajio

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Hiroshi Kajio, MD, Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Tetsuro Kobayashi

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Koji Nakanishi

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Minoru Okubo

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Toshihiko Tsukada

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Toshimasa Nakayama

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Nobuhiro Yamada

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Toshio Murase

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Yoshio Yazaki

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • ,
  • Kinori Kosaka

      Affiliations

    • Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    • Departments of Endocrinology and Metabolism and Clinical Chemistry, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan

Received 5 March 1994 ,Accepted 1 November 1994.

References 

  1. Kobayashi T, Tamemoto K, Nakanishi K, et al.  Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care. 1993;16:780–788
  2. Kobayashi T. Immunology and immunogenetics of type I diabetes in Japan. Int Diabetes Fed Bull. 1990;35:34–37
  3. Maclaren N, Lafferty K. Perspectives in diabetes. In: The 12th International Immunology and Diabetes Workshop. Orlando, Florida. ed 12. Diabetes. 42:1993;p. 1099–1104
  4. Ginsberg-Fellner F, Dobersen MJ, Witt ME, et al.  HLA antigens, cytoplasmic islet cell antibodies, and carbohydrate tolerance in families of children with insulin-dependent diabetes mellitus. Diabetes. 1982;31:292–298
  5. Rich SS, Panter SS, Goetz FC, et al.  Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: Contributions of HLA and haptoglobin. Diabetologia. 1991;34:350–355
  6. Stern MP, Ferrell RE, Rosenthal M, et al.  Association between NIDDM, Rh blood group, and haptoglobin phenotype: Results from the San Antonio Heart Study. Diabetes. 1986;35:387–391
  7. Klint CR, Prout TE, Bradley RF, et al.  Standardization of the oral glucose tolerance test: Report of the Committee on Statistics of the American Diabetes Association, June 14, 1968. Diabetes. 1969;18:297–307
  8. Marble A, Ferguson BD. Diagnosis and classification of diabetes mellitus and the non diabetic meliturias. In:  Marble A,  Krall LP,  Bradley RF, et al. editor. Joslin's Diabetes Mellitus. ed 12. Philadelphia, PA: Lea & Febiger; 1985;p. 332–352
  9. Kobayashi T, Sugimoto T, Itoh T, et al.  The prevalence of islet cell antibodies in Japanese insulin-dependent and non-insulin-dependent diabetic patients studied by indirect immunofluorescence and by a new method. Diabetes. 1986;35:335–340
  10. Kobayashi T, Itoh T, Kosaka K, et al.  Time course of islet cell antibodies and B-cell function in non-insulin-dependent stage of type I diabetes. Diabetes. 1987;36:510–517
  11. Boitard C, Bonifacio E, Bottazzo GF, et al.  In: Immunology and diabetes workshops: Report on the Third International (stage 3) Workshop on Standardization of Cytoplasmic Islet Cell Antibodies. Diabetologia. 31:1988;p. 451–452
  12. Terasaki PI. HLA-DR joint report. In:  Terasaki PI editors. Histocompatibility Testing, 1980. Los Angeles, CA: UCLA Tissue Typing Laboratory; 1980;p. 21
  13. Roy RB, Shaw RW, Connell GE. A simple method for the quantitative determination of serum haptoglobin. J Lab Clin Med. 1969;74:698–704
  14. Gorsuch AN, Spencer KM, Lister J, et al.  Evidence for a long prediabetic period in type I (insulin-dependent) diabetes mellitus. Lancet. 1981;1:1363–1365
  15. Spencer KM, Tarn A, Dean BM, et al.  Fluctuating islet-cell autoimmunity in unaffected relatives of patients with insulin-dependent diabetes. Lancet. 1984;1:764–766
  16. Tarn AC, Thomas JM, Dean BM, et al.  Predicting insulin-dependent diabetes. Lancet. 1988;1:845–850
  17. Bonifacio E, Bingley PJ, Shattock M, et al.  Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet. 1990;335:147–149
  18. Srikanta S, Ganda OP, Rabizadeh A, et al.  First-degree relatives of patients with type I diabetes mellitus: Islet-cell antibodies and abnormal insulin secretion. N Engl J Med. 1985;313:461–464
  19. Rilay WJ, Maclaren NK, Krischer J, et al.  A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med. 1990;323:1167–1172
  20. Thivolet C, Beaufrère B, Geburher L, et al.  Autoantibodies and genetic factors associated with the development of type 1 (insulin-dependent) diabetes mellitus in first degree relatives of diabetic patients. Diabetologia. 1991;34:186–191
  21. Barbosa J, Chavers B, Dunsworth T, et al.  Islet-cell antibodies and histocompatibility antigens (HLA) in insulin-dependent diabetics and their first-degree relatives. Diabetes. 1982;31:585–588
  22. Deschamps I, Homberg JC, Janssen F, et al.  Islet-cell antibodies (ICA-CFICA) and HLA genotypes in 107 IDD patients and their first-degree relatives. Hum Immunol. 1984;10:129–134
  23. Chase HP, Voss MA, Butler-Simon N, et al.  Diagnosis of pre-type I diabetes. J Pediatr. 1987;111:807–812
  24. Deschamps I, Boitard C, Hors J, et al.  Life table analysis of the risk of type 1 (insulin-dependent) diabetes mellitus in siblings according to islet-cell antibodies and HLA markers: An 8-year prospective study. Diabetologia. 1992;35:951–957
  25. Khalil I, Descamps I, Lepage V, et al.  Dose effect of cis- and trans-encoded DQab heterodimers in IDDM susceptibility. Diabetes. 1992;41:378–384
  26. Ronningen KS, Spurkland A, Iwe T, et al.  Distribution of HLA-DRB1, DQA1, and DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Tissue Antigens. 1991;3:105–111
  27. Kobayashi T, Nakanishi K, Sugimoto T, et al.  Maleness as risk factor for slowly progressive IDDM. Diabetes Care. 1989;12:7–11
  28. Nakanishi K, Kobayashi T, Sugimoto T, et al.  Predictive value of insulin autoantibodies for further progression of beta cell dysfunction in non-insulin-dependent diabetics. Diabetes Res. 1988;9:105–109
  29. Kobayashi T, Sawano S, Itoh T, et al.  Islet-cell antibodies in insulin-dependent and non-insulin-dependent diabetics in Japan: Their prevalence and clinical significance. In:  Mimura G,  Baba S,  Goto Y, et al. editor. Clinico-Genetic Genesis of Diabetes Mellitus. Amsterdam, The Netherlands: Excerpta Medica; 1982;p. 150–160
  30. Groop LC, Bottazzo GF, Doniach D. Islet-cell antibodies identify latent type I diabetes in patients aged 35–75 years at diagnosis. Diabetes. 1986;35:237–241
  31. Niskanen L, Karjalainen J, Sarlung H, et al.  Five-year follow-up of islet-cell antibodies in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1991;34:402–408
  32. Oka Y, Katagiri H, Yazaki Y, et al.  Mitochondrial gene mutation in islet-cell-antibody-positive patients who were initially non-insulin-dependent diabetes. Lancet. 1993;342:527–528
  33. McCulloch DK, Klaff LJ, Kahn SE, et al.  Nonprogression of subclinical B-cell dysfunction among first-degree relations of IDDM patients: 5-Yr follow-up of the Seattle Family Study. Diabetes. 1990;39:549–556
  34. Thivolet C, Beaufrére B, Bétuel H, et al.  Islet-cell and insulin autoantibodies in subjects at high risk for development of type 1 (insulin-dependent) diabetes mellitus: The Lyon Family Study. Diabetologia. 1988;31:741–746
  35. Trucco M. To be or not to be ASP 57, that is the question. Diabetes Care. 1992;15:705–715
  36. Iyengar S, Hamman RF, Marshall JA, et al.  Genetic studies of type 2 (non-insulin-dependent) diabetes mellitus: Lack of association with seven genetic markers. Diabetologia. 1989;32:690–693

 Supported in part by grants from the Ministry of Health and Welfare and the Ministry of Education, Science, and Culture of Japan.

PII: 0026-0495(95)90239-2

Metabolism - Clinical and Experimental
Volume 44, Issue 7 , Pages 869-875 , July 1995