Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life☆☆☆
Received 24 October 2001; accepted 16 October 2002.
Abstract
In a case control study of genetic and lifestyle risk factors for Alzheimer's disease (AD), we obtained recalled food consumption frequencies translated to nutrients and averaged over 2 age periods of adult life, 20 to 39 and 40 to 59 years. The proportion of controls with the apolipoprotein E ϵ4 (APOE ϵ4) genotype was significantly higher in the lowest tertile of fat consumption (36.3% of energy) compared with controls with ϵ4 in the highest tertile of fat intake (44.6% of energy). Healthy older persons with the ϵ4 allele who survived to be included in this study may be protected with lower dietary fat intake and other healthy behaviors. Diet-genotype interactions may have important influences on disorders of later life. Copyright 2003, Elsevier Science (USA). All rights reserved.
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Department of Nutrition, The University Memory and Aging Center, Cleveland; and the Departments of Epidemiology and Biostatistics and Neurology, School of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH.
☆ Supported in part by Grant No. P50 AG 08012 from the National Institute on Aging, the Joseph and Florence Mandel Foundation, the Nickman family, The Institute for the Study of Aging, NY, Philip Morris, USA, and The Fullerton Family Foundation.
☆☆ Address reprint requests to Grace J. Petot, MS, University Memory and Aging Center, 12200 Fairhill Rd, Cleveland, OH 44120-1013.
ABSTRACT