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Metabolism - Clinical and Experimental
Volume 52, Issue 3
, Pages 303-307
, March 2003
Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy
References
-
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine.
Proc Natl Acad Sci USA. 1990;87:8612–8616
-
Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase.
Circulation. 1999;99:3092–3095
- Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia. Circulation. 1998;98:1842–1847
- Endogenous nitric oxide synthase inhibitor, a novel marker of atherosclerosis. Circulation. 1999;99:1141–1146
- Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension. J Cardiovasc Pharmacol. 1999;33:652–658
- Vascular endothelial cell activation associated with increased plasma asymmetric dimethyl arginine in children and young adults with hypertension: A basis for atheroma?. Blood Press. 2000;9:16–21
- Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet. 2001;358:2127–2128
- Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963–974
-
.
Endothelial dysfunction in diabetes mellitus.
J Cardiovasc Pharmacol. 1998;32(suppl 3):54–61
- . Diabetes and atherosclerosis: An epidemiologic view. Diabetes Metab Rev. 1987;3:463–524
- Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229–234
- . The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373–376
- L-arginine-nitric oxide pathway-related metabolites in the aqueous humor of diabetic patients. Invest Ophthalmol Vis Sci. 2000;41:213–217
- Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998;97:1129–1135
- Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum. Zhongguo Yao Li Xue Bao. 1997;18:511–514
- Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. Br J Pharmacol. 1999;126:211–218
- Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol. 2001;88:1201–1203
- Glomerular filtration rate and kidney size after six years disease duration in non-insulin-dependent diabetic subjects. Clin Nephrol. 1996;45:10–17
- Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: Relation to glomerular hyperfiltration. Diabetes. 2000;49:1258–1263
- Hyperfiltration in African-American patients with type 2 diabetes. Cross-sectional and longitudinal data. Diabetes Care. 1998;21:2129–2134
- Measurement of hemoglobin A1c by a new liquid-chromatographic assay: Methodology, clinical utility, and relation to glucose tolerance evaluated. Clin Chem. 1986;32:1867–1872
- Determinations of asymmetrical dimethylarginine by capillary electrophoresis-laser-induced fluorescence. J Chromatogr B Biomed Sci Appl. 2000;741:77–83
- Improved method for simultaneous determination of L-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 2000;742:199–203
- Determination of arginine and methylated arginines in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000;748:157–166
- High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 1997;96:25–28
- Exposure to elevated D-glucose concentrations modulates vascular endothelial cell vasodilatory response. Diabetes. 1993;42:1497–1505
- . Pathogenesis, prevention and treatment of diabetic nephropathy. Lancet. 1998;352:213–219
- . Nitric oxide in diabetic nephropathy. Kidney Int Suppl. 1997;60:S46–S53
- Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes. Nephron. 1996;74:136–143
- . Superoxide anion curbs nitric oxide modulation of afferent arteriolar ANG II responsiveness in diabetes mellitus. Am J Physiol Renal Physiol. 2000;278:F302–F309
-
.
The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy.
Diabetes. 1983;32(suppl 2):64–78
- Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 1992;339:572–575
- Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease. J Am Soc Nephrol. 2002;13:170–176
- Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinaemia and occlusive retinal vascular disease in type 2 diabetic and nondiabetic subjects. Clin Nephrol. 2002;58:171–178
- . Long-term glycaemic control directly correlates with glomerular filtration rate in early type 1 diabetes mellitus before the onset of microalbuminuria. Diabet Med. 1998;15:1010–1014
- Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol. 1998;178:551–556
-
Elevated plasma level of asymmetric dimethylarginine (ADMA) is associated with atherosclerotic disease of the thoracic aorta.
J Am Coll Cardiol. 2001;37:648A;
(suppl A, abstr)
- Plasma asymmetric dimethylarginine and hyperemic myocardial blood flow in young subjects with borderline hypertension or familial hypercholesterolemia. J Am Coll Cardiol. 2002;40:1241–1247
☆ Supported by grants from the Elli and Elvi Oksanen Fund of the Pirkanmaa Fund under the auspices of Finnish Cultural Foundation, the Juho Vainio Foundation, and the Medical Research Fund of the Tampere University Hospital.
☆☆ Address reprint requests to Hannu Päivä, MD, Tampere University Hospital, Department of Internal Medicine, PO Box 2000, FIN-33521, Tampere, Finland.
PII: S0026-0495(02)05264-2
doi: 10.1053/meta.2003.50048
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Metabolism - Clinical and Experimental
Volume 52, Issue 3
, Pages 303-307
, March 2003
