Metabolism - Clinical and Experimental
Volume 52, Issue 3 , Pages 308-314 , March 2003

Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: Protection by nitric oxide donor

Received 6 April 2002 ,Accepted 28 September 2002.

References 

  1. Kannel WB, McGee DL. Diabetes and cardiovascular disease: The Framingham Study. JAMA. 1978;24:2.35–238
  2. Yla-Herttula S. Oxidized LDL and atherosclerosis. Ann NY Acad Sci. 1999;30:134–137
  3. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med. 1996;20:707–727
  4. Parthasarathy S, Barnett J. Phospholipase A2 activity of low density lipoprotein: Evidence for an intrinsic phospholipase A2 activity of apoprotein B-100. Proc Natl Acad Sci USA. 1990;87:9741–9745
  5. McIntyre TM, Zimmerman GA, Prescott SM. Biologically active oxidized phospholipids. J Biol Chem. 1999;274:25189–25192
  6. Si AH, Yoshinari M, Wakisaka M, et al.  Lysophosphatidylcholine molecular species in low density lipoprotein of type 2 diabetes. Horm Metab Res. 1999;31:283–286
  7. Takahara N, Kashiwagi A, Nishio Y, et al.  Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells. Diabetologia. 1997;40:662–670
  8. Sonoki K, Yoshinari M, Iwase M, et al.  Glycoxidized low-density lipoprotein enhances MCP-1 mRNA expression in HUVEC. Relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor. Metabolism. 2002;51:1135–1142
  9. Nelken NA, Coughin SR, Gordon D, et al.  Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991;88:1121–1127
  10. Jaffe EA, Nachman RL, Becker CG, et al.  Culture of human endothelial cells derived from umbilical veins. J Clin Invest. 1973;52:2745–2756
  11. Vieira OV, Laranjinha JAN, Madeira VMC, et al.  Rapid isolation of low density lipoproteins in a concentrated fraction free from water-soluble plasma antioxidants. J Lipid Res. 1996;37:2715–2721
  12. Quinn MT, Parthasarathy S, Steinberg D. Lysophosphatidylcholine: A chemotactic factor for human monocytes and its potential role in atherogenesis. Proc Natl Acad Sci USA. 1988;85:2805–2809
  13. Alberti KGMM, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO conclusion. Diabet Med. 1998;15:539–553
  14. Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med. 1976;15:212–216
  15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911–917
  16. Kaluzny MA, Duncan LA, Merritt MV, et al.  Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res. 1985;26:135–140
  17. Han X, Gubitosi-Klug RA, Collins BJ, et al.  Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis. Biochemistry. 1996;35:5822–5832
  18. Schreiber E, Matthias P, Muller MM, et al.  Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res. 1989;17:6419
  19. Sakurai T, Yamamoto Y, Baba N, et al.  Phospholipase A2 activity in non-glycated and glycated low density lipoproteins. Biochim Biophys Acta. 1996;1301:85–89
  20. Sugiyama S, Kugiyama K, Ogata N, et al.  Biphasic regulation of transcription factor nuclear factor-κB activity in human endothelial cells by lysophosphatidylcholine through protein kinase C-mediated pathway. Arterioscler Thromb Vasc Biol. 1998;18:568–576
  21. Takahara N, Kashiwagi A, Maegawa H, et al.  Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells. Metabolism. 1996;45:559–564
  22. Aoyama T, Fujiwara H, Masaki T, et al.  Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol. 1999;31:2101–2114
  23. Nakano T, Raines EW, Abraham JA, et al.  Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes. Proc Natl Acad Sci USA. 1994;91:1069–1073
  24. Jensen PE, Ohanian J, Stausbol-Gron B, et al.  Increase by lysophosphatidylcholines of smooth muscle Ca2+ sensitivity in alpha-toxin-permeabilized small mesenteric artery from the rat. Br J Pharmacol. 1996;117:1238–1244
  25. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acide reaction. Anal Biochem. 1979;95:351–358
  26. Kleinman Y, Krul ES, Burnes M, et al.  Lipolysis of LDL with phospholipase A2 alters the expression of selected apoB-100 epitopes and the interaction of LDL with cells. J Lipid Res. 1988;29:729–743
  27. Sobenin IA, Tertov VV, Orekhov AN. Atherogenic modified LDL in diabetes. Diabetes. 1996;45(suppl 3):S35–S39
  28. Yedgar S, Lichtenberg D, Schnitzer E. Inhibition of phospholipase A2 as a therapeutic target. Biochim Biophys Acta. 2000;1488:182–187
  29. Peng HB, Libby P, Liao JK. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NF-κB. J Biol Chem. 1995;270:14214–14219
  30. Matthews JR, Botting CH, Panico M, et al.  Inhibition of NF-κB DNA binding by nitric oxide. Nucleic Acids Res. 1996;24:2236–2242
  31. Giugliano D, Marfella R, Coppola L, et al.  Vascular effects of acute hyperglycemia in humans are reversed by L-arginine: evidence for reduced availability of nitric oxide during hyperglycemia. Circulation. 1997;95:1783–1790

 Address reprint requests to Masanori Iwase, MD, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

PII: S0026-0495(02)05265-4

doi: 10.1053/meta.2003.50049

Metabolism - Clinical and Experimental
Volume 52, Issue 3 , Pages 308-314 , March 2003