Metabolism - Clinical and Experimental
Volume 52, Issue 3 , Pages 333-337 , March 2003

Short-term dietary adjustment with a hydrolyzed casein–based diet postpones diabetes development in the diabetes-prone BB rat

Received 16 May 2002 ,Accepted 19 September 2002.

References 

  1. Mordes JP, Bortell R, Groen H, et al.  Autoimmune diabetes mellitus in the BB rat. In:  Sima AAF,  Shafrir E editor. Animal Models for Autoimmune Diseases. Amsterdam, the Netherlands: Harwood Academic; 2001;p. 1–41
  2. Knip M, Akerblom HK. Environmental factors in the pathogenesis of type 1 diabetes mellitus. Exp Clin Endocrinol Diabetes. 1999;107(suppl 3):S93–S100
  3. Akerblom HK, Knip M. Putative environmental factors in type 1 diabetes. Diabetes Metab Rev. 1998;14:31–67
  4. Like AA, Kislauskis E, Williams RM, et al.  Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science. 1982;216:644–646
  5. Burstein D, Mordes JP, Greiner DL, et al.  Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes. 1989;38:24–30
  6. Saldeen J. Cytokines induce both necrosis and apoptosis via a common Bcl-2- inhibitable pathway in rat insulin-producing cells. Endocrinology. 2000;141:2003–2010
  7. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev. 1998;14:129–151
  8. Rabinovitch A, Suarez-Pinzon W, El Sheikh A, et al.  Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM. Diabetes. 1996;45:749–754
  9. Kolb H, Worz-Pagenstert U, Kleemann R, et al.  Cytokine gene expression in the BB rat pancreas: Natural course and impact of bacterial vaccines. Diabetologia. 1996;39:1448–1454
  10. Harrison LC, Honeyman MC. Cow's milk and type 1 diabetes: The real debate is about mucosal immune function. Diabetes. 1999;48:1501–1507
  11. Scott FW. Food-induced type 1 diabetes in the BB rat. Diabetes Metab Rev. 1996;12:341–359
  12. Scott FW, Cloutier HE, Kleeman R, et al.  Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats. Diabetes. 1997;46:589–598
  13. Wang GS, Gruber H, Smyth P, et al.  Hydrolyzed casein diet protects BB rats from developing diabetes by promoting islet neogenesis. J Autoimmun. 2000;15:407–416
  14. Todd D, Singh AJ, Greiner DL, et al.  A new isolation method for rat intraepithelial lymphocytes. J Immunol Methods. 1999;224:111–127
  15. Malkani S, Nompleggi D, Hansen JW, et al.  Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Diabetes. 1997;46:1133–1140
  16. Olivares E, Ladriere L, Laghmich A, et al.  Effects of a protective hydrolyzed casein diet upon the metabolic and secretory responses of pancreatic islets to IL-1beta, cytokine production by mesenteric lymph node cells, mitogenic and biosynthetic activities in Peyer's patch cells, and mitogenic activity in pancreatic lymph node cells from control and diabetes-prone BB rats. Mol Genet Metab. 1999;68:379–390
  17. Jansen A, Rosmalen JG, Homo-Delarche F, et al.  Effect of prophylactic insulin treatment on the number of ER-MP23+ macrophages in the pancreas of NOD mice. Is the prevention of diabetes based on beta-cell rest?. J Autoimmun. 1996;9:341–348
  18. Visser J, Groen H, Klatter F, et al.  Timing of pentoxifylline treatment determines its protective effect on diabetes development in the Bio Breeding rat. Eur J Pharmacol. 2002;445:133–140
  19. Lee KU. Nitric oxide produced by macrophages mediates suppression of ConA-induced proliferative responses of splenic leukocytes in the diabetes-prone BB rat. Diabetes. 1994;43:1218–1220
  20. Iwasaki A, Kelsall BL. Mucosal immunity and inflammation. I. Mucosal dendritic cells: Their specialized role in initiating T cell responses. Am J Physiol. 1999;276:G1074–G1078
  21. Sobel DO, Newsome J. Gamma interferon prevents diabetes in the BB rat. Clin Diagn Lab Immunol. 1997;4:764–768
  22. Nicoletti F, Zaccone P, Di Marco R, et al.  Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats. Diabetes. 1998;47:32–38
  23. Kolb H, Pozzilli P. Cow's milk and type I diabetes: The gut immune system deserves attention. Immunol Today. 1999;20:108–110
  24. Cohen IR. The Th1/Th2 dichotomy, hsp60 autoimmunity, and type I diabetes. Clin Immunol Immunopathol. 1997;84:103–106
  25. Pozzilli P. Beta-casein in cow's milk: A major antigenic determinant for type 1 diabetes?. J Endocrinol Invest. 1999;22:562–567
  26. Honeyman MC, Stone NL, Harrison LC. T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA- 2: Potential for mimicry with rotavirus and other environmental agents. Mol Med. 1998;4:231–239

☆ Supported by Research Grants No. 96.606 and 98.148 from the Dutch Diabetes Foundation.

☆☆ Address reprint requests to Jan Rozing, PhD, Department of Cell Biology, Immunology Section, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

PII: S0026-0495(02)05268-X

doi: 10.1053/meta.2003.50052

Metabolism - Clinical and Experimental
Volume 52, Issue 3 , Pages 333-337 , March 2003

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