Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women

Huang, Ji-Biao; Espinoza, Jimmy; Romero, Roberto; Petty, Howard R.

doi:10.1016/j.metabol.2005.09.002

« Previous Next »Metabolism - Clinical and Experimental
Volume 55, Issue 3 , Pages 279-281, March 2006

Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women

Ji-Biao Huang
- Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA
Jimmy Espinoza
- Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
- Hutzel Hospital, Detroit, MI 48201, USA
Roberto Romero
- Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
- Hutzel Hospital, Detroit, MI 48201, USA
Howard R. Petty
- Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA
- Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI 48105, USA
- Corresponding author. Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA. Tel.: +1 734 647 0384; fax: +1 734 936 3815.

Received 14 July 2005; accepted 27 September 2005.

Abstract

To better understand the mechanisms of metabolic microcompartmentalization associated with neutrophil hexose monophosphate shunt activity during pregnancy, we have studied the intracellular trafficking of glucose-6-phosphate dehydrogenase (G6PDase). Microtubule motor proteins colocalize with G6PDase. Dynein inhibitors block G6PDase accumulation at the microtubule-organizing center in pregnancy cells. On this basis, we conclude that microtubule motor proteins participate in hexose monophosphate shunt enzyme transport within leukocytes.