Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women
Received 14 July 2005; accepted 27 September 2005.
Abstract
To better understand the mechanisms of metabolic microcompartmentalization associated with neutrophil hexose monophosphate shunt activity during pregnancy, we have studied the intracellular trafficking of glucose-6-phosphate dehydrogenase (G6PDase). Microtubule motor proteins colocalize with G6PDase. Dynein inhibitors block G6PDase accumulation at the microtubule-organizing center in pregnancy cells. On this basis, we conclude that microtubule motor proteins participate in hexose monophosphate shunt enzyme transport within leukocytes.
aDepartment of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA
bDepartment of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI 48105, USA
cPerinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
Corresponding author. Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA. Tel.: +1 734 647 0384; fax: +1 734 936 3815.
ABSTRACT