Metabolism of γ-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase

Struys, Eduard A.; Verhoeven, Nanda M.; Jansen, Erwin E.W.; ten Brink, Herman J.; Gupta, Maneesh; Burlingame, Terry G.; Quang, Lawrence S.; Maher, Timothy; Rinaldo, Piero; Snead, O. Carter; Goodwin, Amy K.; Weerts, Elise M.; Brown, P. Rand; Murphy, Tonya C.; Picklo, Mathew J.; Jakobs, Cornelius; Gibson, K. Michael

doi:10.1016/j.metabol.2005.09.009

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Volume 55, Issue 3 , Pages 353-358, March 2006

Metabolism of γ-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase

Preliminary data were presented at the 41st Annual Meeting of the Society for the Study of Inborn Errors of Metabolism, Amsterdam, the Netherlands, 2004.

Eduard A. Struys
- Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Nanda M. Verhoeven
- Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Erwin E.W. Jansen
- Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Herman J. ten Brink
- Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Maneesh Gupta
- Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
Terry G. Burlingame
- Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
Lawrence S. Quang
- Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Timothy Maher
- Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA
Piero Rinaldo
- Biochemical Genetics Laboratory, Mayo Clinic College of Medicine, Rochester, MN, USA
O. Carter Snead
- Division of Neurology and The Program in Brain and Behavior, Department of Pediatrics, Faculty of Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Amy K. Goodwin
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Elise M. Weerts
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
P. Rand Brown
- Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Tonya C. Murphy
- Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
Mathew J. Picklo
- Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
Cornelius Jakobs
- Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
K. Michael Gibson
- Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
- Division of Medical Genetics, Departments of Pediatrics and Pathology, University of Pittsburgh School of Medicine and Children's Hospital, Pittsburgh, PA 15213, USA
- Corresponding author. Division of Medical Genetics, Departments of Pediatrics and Pathology, University of Pittsburgh School of Medicine, Rangos Research Center, Pittsburgh, PA 15213, USA. Tel.: +1 412 692 7608; fax: +1 412 692 7816.