Metabolism - Clinical and Experimental
Volume 55, Issue 3 , Pages 366-370 , March 2006

Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus

  • Sun-Young Kim

      Affiliations

    • Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • ,
  • Dae-Sun Jo

      Affiliations

    • Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • ,
  • Pyoung Han Hwang

      Affiliations

    • Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • ,
  • Ji Hyun Park

      Affiliations

    • Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • ,
  • Sung Kwang Park

      Affiliations

    • Renal Regeneration Laboratory, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • ,
  • Ho Keun Yi

      Affiliations

    • Department of Biochemistry, School of Dentistry, Chonbuk National University, Jeonju, Korea
    • ,
  • Dae-Yeol Lee

      Affiliations

    • Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Chonbuk National University Hospital, Keumam-dong, Jeonju, Jeonbuk 561-712, Korea. Tel.: +82 63 250 1469; fax: +82 63 250 1464.

Received 22 April 2005 ,Accepted 22 September 2005.

References 

  1. Kojima M, Hosoda H, Date Y, et al. Ghrelin is growth hormone–releasing acylated peptide from stomach. Nature. 1999;402:656–660
  2. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992–5995
  3. Mori K, Ahihiro Yoshimoto A, et al. Kidney produces a novel acylated peptide, ghrelin. FFBS Lett. 2000;486:213–216
  4. Hosoda H, Kojima M, Matsuo H, et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2000;279:909–913
  5. Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun. 2001;281:1220–1225
  6. Lee HM, Wang G, Englander EW, et al. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology. 2002;143:185–190
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  9. Yoshimoto A, Mori K, Sugawara A, et al. Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol. 2002;13:2748–2752
  10. Ukkola O, Ravussin E, Jacobson P, et al. Role of ghrelin polymorphism in obesity based on three different studies. Obes Res. 2002;10:782–791
  11. Korbonits M, Gueorguiev M, O'Grady E, et al. A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab. 2002;87:4005–4008
  12. Ukkola O, Kesanniemi YA. Preproghrelin Leu72Zmet polymorphism in patients with type 2 diabetes mellitus. J Int Med. 2003;254:391–394
  13. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complication: I. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–553
  14. Feld S, Hirschberg R. Growth hormone, the insulin-like growth factor system, and the kidney. Endocr Rev. 1996;17:423–468
  15. Haylor J, Singh I, el Nahas AM. Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I. Kidney Int. 1991;39:333–335
  16. Wajnrajch MP, Ten IS, Gertner JM, et al. Genomic organization of the ghrelin gene. J Endocr Genet. 2000;1:231–233
  17. Misquitta CM, Iyer VR, Werdyiuk ES, et al. The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology. Mol Cell Biochem. 2001;224:53–67
  18. Tanaka M, Hayashida Y, Nakao N, et al. Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim Biophys Acta. 2001;1522:62–65
  19. Pöykkö S, Ukkola O, Kauma H, et al. Ghrelin Arg51Gln mutation is a risk factor for type 2 diabetes and hypertension in a random sample of middle-aged subjects. Diabetologia. 2003;46:455–458
  20. Stenvinkel P, Pecoits-Filho R, Lindholm B. Leptin, ghrelin and proinflammatory cytokines: compounds with nutritional impact in chronic renal disease?. Adv Ren Replace Ther. 2003;10:332–345

PII: S0026-0495(05)00368-9

doi: 10.1016/j.metabol.2005.09.011

Metabolism - Clinical and Experimental
Volume 55, Issue 3 , Pages 366-370 , March 2006

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