Metabolism - Clinical and Experimental
Volume 55, Issue 3 , Pages 371-380 , March 2006

Antecedent hypoglycemia does not alter increased epinephrine-induced lipolysis in type 1 diabetes mellitus

  • Robert P. Hoffman

      Affiliations

    • Corresponding Author InformationChildren's Hospital ED541, Columbus, OH 43205, USA. Tel.: +1 614 722 4425; fax: +1 614 722 4440.

Received 19 May 2005 ,Accepted 12 September 2005.

References 

  1. Hoffman RP, Arslanian S, Drash AL, et al. Glucagon and epinephrine deficiency in children and adolescents, with new onset IDDM. J Pediatr Endocrinol. 1994;7:235–244
  2. Hoffman RP, Singer-Granick C, Drash AL, et al. Plasma catecholamine responses to hypoglycemia in children and adolescents with IDDM. Diabetes Care. 1991;14:81–88
  3. Kleinbaum J, Shamoon H. Impaired counterregulation of hypoglycemia in insulin-dependent diabetes mellitus. Diabetes. 1983;32:493–498
  4. Simonson DC, Tamborlane WV, DeFronzo RA, et al. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type 1 diabetes. Ann Intern Med. 1985;103:184–190
  5. Dagogo-Jack S, Craft S, Cryer PE. Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus: recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against hypoglycemia. J Clin Invest. 1993;91:819–828
  6. Hvidberg A, Fanelli CG, Hershey TM, et al. Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in non-diabetic humans. Diabetes. 1996;45:1030–1036
  7. Davis SN, Shavers C, Mosqueda-Garcia R, et al. Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans. Diabetes. 1997;46:1328–1335
  8. Berlin I, Grimwaldi A, Landult C, et al. Lack of hypoglycemic symptoms and decreased beta-adrenergic sensitivity in insulin dependent diabetic patients. J Clin Endocrinol Metab. 1988;66:273–278
  9. Korytkowski MT, Mokan M, Veneman TF, et al. Reduced β-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemic unawareness. Diabetes Care. 1998;21:1939–1943
  10. Trovik TS, Jaeger R, Jorde R, et al. Reduced sensitivity to beta-adrenergic stimulation and blockade in insulin-dependent diabetic patients with hypoglycemia unawareness. Br J Clin Pharmacol. 1994;38:427–432
  11. Fritsche A, Stumvall M, Grub M, et al. Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects. Diabetes Care. 1998;21:1505–1510
  12. Fritsche A, Stumvall M, Haring HU, et al. Reversal of hypoglycemic unawareness in a long-term diabetic patient by improvement of β-adrenergic sensitivity after prevention of hypoglycemia. J Clin Endocrinol Metab. 2000;85:523–525
  13. Vea H, Trovik TS, Sager G, et al. Return of beta-adrenergic sensitivity in a patient with insulinoma after removal of the tumor. Diabet Med. 1997;14:979–984
  14. Galassetti P, Tate D, Neill RA, et al. Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes. Diabetes. 2003;52:1761–1769
  15. McGuinness OP, Shau V, Benson EM, et al. Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog. Am J Physiol. 1997;273:E674–E681
  16. Purdon C, Brousson M, Nyveen SL, et al. The roles of insulin and catecholamines in the glucoregulatory response during intense exercise and early recovery in insulin dependent diabetic and control subjects. J Clin Endocrinol Metab. 1993;76:566–573
  17. Capaldo B, Napoli R, DiMarino L, et al. Epinephrine directly antagonizes insulin-mediated activation of glucose uptake and inhibition of free fatty acids release in forearm tissues. Metabolism. 1992;41:1146–1149
  18. Kollind M, Adamson U, Lins PE, et al. Transient insulin resistance following infusion of adrenaline in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1988;31:603–606
  19. Avogaro A, Gnudi L, Valerio A, et al. Effects of different plasma glucose concentrations of lipolytic and ketogenic responsiveness to epinephrine in type 1 (insulin-dependent) diabetic subjects. J Clin Endocrinol Metab. 1993;76:845–850
  20. Boden G, Chen X, Ruiz J, et al. Mechanisms of fatty acid–induced inhibition of glucose uptake. J Clin Invest. 1994;93:2438–2446
  21. Randle PJ, Garland PB, Hales CN, et al. The glucose–fatty acid cycle; its role in insulin sensitivity and the metabolic disturbances if diabetes mellitus. Lancet. 1963;i:785–789
  22. Davis SN, Shavers C, Costa F. Gender-related differences in counterregulatory responses to antecedent hypoglycemia in normal humans. J Clin Endocrinol Metab. 2000;85:2148–2157
  23. Hoffman RP, Sinkey CA, Dopp JM, et al. Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects. Diabetes. 2002;51:734–742
  24. Divertie GD, Jensen MD, Cryer PE, et al. Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans. Am J Physiol. 1997;272:E1130–E1135
  25. DeFronzo RA, Tobin JD, Anfres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214–E223
  26. Hausberg M, Sinkey CA, Mark AL, et al. Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents. Am J Hypertens. 1998;11:1312–1320
  27. Hoffman RP, Sinkey CA, Tsalikian E. Effect of local adrenergic blockade of forearm blood flow and glucose uptake during hypoglycemia. Metabolism. 1999;48:1575–1585
  28. Enoksson S, Caprio SK, Rife F, et al. Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia. J Clin Endocrinol Metab. 2003;88:1503–1511
  29. Cohen N, Halberstam M, Rossetti I, et al. Increased lipid oxidation but normal muscle glycogen response to epinephrine in humans with IDDM. Am J Physiol. 1996;271:E284–E293
  30. Avogaro A, Valerio A, Gnudi L, et al. The effects of different plasma insulin concentrations on lipolytic responses to epinephrine in normal and type 1 (insulin-dependent) diabetic humans. Diabetologia. 1992;35:129–138
  31. Bolinder J, Sjoberg S, Arner P. Stimulation of adipose tissue lipolysis following insulin-induced hypoglycemia: evidence for increased beta-adrenergic–mediated lipolytic response in IDDM. Diabetologia. 1996;39:845–853
  32. Davis SN, Fowler S, Costa F. Hypoglycemic counterregulatory responses differ between men and women with type 1 diabetes. Diabetes. 2000;49:65–72
  33. Qvisth V, Hagstrom-Toft E, Enoksson S, et al. Combined hyperinsulinemia and hyperglycemia, but not hyperinsulinemia alone, suppress human skeletal muscle lipolytic activity in vivo. J Clin Endocrinol Metab. 2004;89:4693–4700
  34. Wahrenberg H, Lonnqvist F, Engfeldt P, et al. Abnormal action of catecholamines on lipolysis in adipocytes of type 1 diabetes patients treated with insulin. Diabetes. 1989;38:524–533
  35. Flechtner-Mors M, Ditschuuneit HH, Yip I, Adler G. Sympathetic modulation of lipolysis in subcutaneous adipose tissue: effects of gender and energy restriction. J Lab Clin Med. 1999;134:33–41
  36. Hoffman RP, Sinkey CA, Kienzle MG, Anderson EA. Muscle sympathetic nerve activity is reduced in IDDM before the onset of overt autonomic neuropathy. Diabetes. 1993;42:375–380

PII: S0026-0495(05)00369-0

doi: 10.1016/j.metabol.2005.09.012

Metabolism - Clinical and Experimental
Volume 55, Issue 3 , Pages 371-380 , March 2006