Metabolism - Clinical and Experimental
Volume 55, Issue 12 , Pages 1564-1568 , December 2006

Hyperhomocysteinemia: a novel risk factor for erectile dysfunction

  • Tevfik Demir

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Endocrinology and Metabolism, Izmir, Turkey
    • ,
  • Abdurrahman Çomlekçi

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Endocrinology and Metabolism, Izmir, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 232 412 37 42; fax: +90 232 279 22 67.
    • ,
  • Omer Demir

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Urology, Izmir, Turkey
    • ,
  • Aytaç Gülcü

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Radiology, Izmir, Turkey
    • ,
  • Sezer Çalýþkan

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Biochemistry, Izmir, Turkey
    • ,
  • Leyla Argun

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Biochemistry, Izmir, Turkey
    • ,
  • Mustafa Seçil

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Radiology, Izmir, Turkey
    • ,
  • Sena Yeþil

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Endocrinology and Metabolism, Izmir, Turkey
    • ,
  • Adil Esen

      Affiliations

    • Dokuz Eylul University, School of Medicine, Department of Urology, Izmir, Turkey

Received 29 December 2005 ,Accepted 27 March 2006.

References 

  1. Maas R, Schwedhelm E, Albsmeier J, et al. The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med. 2002;7:213–225
  2. Ungvari Z, Csiszar A, Bagi Z, et al. Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia. Morphological and functional evidence for increased peroxynitrite formation. Am J Pathol. 2002;161:145–153
  3. Stampfer MJ, Malinow MR, Willett WC. A prospective study of plasma homoscyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;268:877–881
  4. Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997;277:1775–1781
  5. Austin RC, Lentz SR, Werstuck GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ. 2004;11(Suppl 1):S56–S64
  6. Rosen RC, Riley A, Wagner G, et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822–830
  7. Feldman HA, Goldstein I, Hatzichristou DG, et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54–61
  8. Khan MA, Thompson CS, Emsley AM, et al. The interaction of homocysteine and copper markedly inhibits the relaxation of rabbit corpus cavernosum: new risk factors for angiopathic erectile dysfunction?. BJU Int. 1999;84:720–724
  9. Jones RW, Jeremy JY, Koupparis A, et al. Cavernosal dysfunction in a rabbit model of hyperhomocysteinanemia. BJU Int. 2005;95:125
  10. Bots ML, Launer LJ, Lindemans J, et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study. Arch Intern Med. 1999;159:38–44
  11. Rasouli ML, Nasir K, Blumenthal RS, et al. Plasma homocysteine predicts progression of atherosclerosis. Atherosclerosis. 2005;181:159–165
  12. Virag R. Flow-dependent dilatation of the cavernous artery. A potential test of penile NO content. J Mal Vasc. 2002;27:214–217
  13. Tawakol A, Omland TMP, Gerhard MM, et al. Hyperhomocysteinemia is associated with impaired endothelium dependent vasodilation in humans. Circulation. 1997;95:1119–1121
  14. Boger RH, Bode-Boger SM, Sydow K, et al. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2000;20:1557–1564
  15. Stuhlinger MC, Oka RK, Graf EE, et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation. 2003;108:933–938
  16. Bank AJ, Billups KL, Kaiser DR, et al. Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with erectile dysfunction. Int J Impot Res. 2003;15:231–236
  17. Strassburg A, Krems C, Luhrmann PM, et al. Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors. Int J Vitam Nutr Res. 2004;74:129–136
  18. Zamboni M, Di Francesco V, Zoico E, et al. Homocysteine and life-style in the elderly. Aging (Milano). 2001;13:437–442

PII: S0026-0495(06)00122-3

doi: 10.1016/j.metabol.2006.03.019

Metabolism - Clinical and Experimental
Volume 55, Issue 12 , Pages 1564-1568 , December 2006

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