Metabolism - Clinical and Experimental
Volume 56, Issue 8 , Pages 1051-1059 , August 2007

The thermogenic and metabolic effects of protein hydrolysate with or without a carbohydrate load in healthy male subjects

  • Mandy Claessens

      Affiliations

    • Nutrition and Toxicology Research institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 43 3881405; fax: +31 43 3670976.
    • ,
  • Wim Calame

      Affiliations

    • Kerry Group Nutrition Technical Center, Veluwezoom 62, 1327 AH Almere, The Netherlands
    • ,
  • André D. Siemensma

      Affiliations

    • Kerry Group Nutrition Technical Center, Veluwezoom 62, 1327 AH Almere, The Netherlands
    • ,
  • Wim H.M. Saris

      Affiliations

    • Nutrition and Toxicology Research institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • Marleen A. van Baak

      Affiliations

    • Nutrition and Toxicology Research institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands

References 

  1. Eisenstein J, Roberts SB, Dallal G, Saltzman E. High-protein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data. Nutr Rev. 2002;60:189–200
  2. Johnston CS, Tjonn SL, Swan PD. High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults. J Nutr. 2004;134:586–591
  3. Westerterp-Plantenga MS, Lejeune MP, Nijs I, van Ooijen M, Kovacs EM. High protein intake sustains weight maintenance after body weight loss in humans. Int J Obes Relat Metab Disord. 2004;28:57–64
  4. Lejeune MP, Westerterp KR, Adam TC, Luscombe-Marsh ND, Westerterp-Plantenga MS. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr. 2006;83:89–94
  5. Raben A, Agerholm-Larsen L, Flint A, Holst JJ, Astrup A. Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake. Am J Clin Nutr. 2003;77:91–100
  6. Johnston CS, Day CS, Swan PD. Postprandial thermogenesis is increased 100% on a high-protein, low-fat diet versus a high-carbohydrate, low-fat diet in healthy, young women. J Am Coll Nutr. 2002;21:55–61
  7. Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond). 2005;108:185–194
  8. Kabadi UM. Dose-kinetics of pancreatic alpha- and beta-cell responses to a protein meal in normal subjects. Metabolism. 1991;40:236–240
  9. Calbet JA, MacLean DA. Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans. J Nutr. 2002;132:2174–2182
  10. Jiang G, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab. 2003;284:E671–E678
  11. Nair KS. Hyperglucagonemia increases resting metabolic rate in man during insulin deficiency. J Clin Endocrinol Metab. 1987;64:896–901
  12. Perea A, Clemente F, Martinell J, Villanueva-Penacarrillo ML, Valverde I. Physiological effect of glucagon in human isolated adipocytes. Horm Metab Res. 1995;27:372–375
  13. Carlson MG, Snead WL, Campbell PJ. Regulation of free fatty acid metabolism by glucagon. J Clin Endocrinol Metab. 1993;77:11–15
  14. Bertin E, Arner P, Bolinder J, Hagstrom-Toft E. Action of glucagon and glucagon-like peptide-1-(7-36) amide on lipolysis in human subcutaneous adipose tissue and skeletal muscle in vivo. J Clin Endocrinol Metab. 2001;86:1229–1234
  15. Gravholt CH, Moller N, Jensen MD, Christiansen JS, Schmitz O. Physiological levels of glucagon do not influence lipolysis in abdominal adipose tissue as assessed by microdialysis. J Clin Endocrinol Metab. 2001;86:2085–2089
  16. Westphal SA, Gannon MC, Nuttall FQ. Metabolic response to glucose ingested with various amounts of protein. Am J Clin Nutr. 1990;52:267–272
  17. Calbet JA, Holst JJ. Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans. Eur J Nutr. 2004;43:127–139
  18. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. 1949. J Physiol. 1949;109:1–9
  19. Anonymous . Zo eet Nederland, 1998. Resultaten van de Voedselconsumptiepeiling 1997-1998. Drukkerij ten Brink. 1998;
  20. Robinson SM, Jaccard C, Persaud C, Jackson AA, Jequier E, Schutz Y. Protein turnover and thermogenesis in response to high-protein and high-carbohydrate feeding in men. Am J Clin Nutr. 1990;52:72–80
  21. Nair KS, Halliday D, Garrow JS. Thermic response to isoenergetic protein, carbohydrate or fat meals in lean and obese subjects. Clin Sci (Lond). 1983;65:307–312
  22. Karst H, Steiniger J, Noack R, Steglich HD. Diet-induced thermogenesis in man: thermic effects of single proteins, carbohydrates and fats depending on their energy amount. Ann Nutr Metab. 1984;28:245–252
  23. Swaminathan R, King RF, Holmfield J, Siwek RA, Baker M, Wales JK. Thermic effect of feeding carbohydrate, fat, protein and mixed meal in lean and obese subjects. Am J Clin Nutr. 1985;42:177–181
  24. Crovetti R, Porrini M, Santangelo A, Testolin G. The influence of thermic effect of food on satiety. Eur J Clin Nutr. 1998;52:482–488
  25. Pannemans DL, Halliday D, Westerterp KR, Kester AD. Effect of variable protein intake on whole-body protein turnover in young men and women. Am J Clin Nutr. 1995;61:69–74
  26. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev. 1997;77:731–758
  27. Nuttall FQ, Mooradian AD, Gannon MC, Billington C, Krezowski P. Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load. Diabetes Care. 1984;7:465–470
  28. Krezowski PA, Nuttall FQ, Gannon MC, Bartosh NH. The effect of protein ingestion on the metabolic response to oral glucose in normal individuals. Am J Clin Nutr. 1986;44:847–856
  29. Rabinowitz D, Merimee TJ, Maffezzoli R, Burgess JA. Patterns of hormonal release after glucose, protein, and glucose plus protein. Lancet. 1966;2:454–456
  30. Katz J, McGarry JD. The glucose paradox. Is glucose a substrate for liver metabolism?. J Clin Invest. 1984;74:1901–1909
  31. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999;103:E26
  32. Meier JJ, Kjems LL, Veldhuis JD, Lefebvre P, Butler PC. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes. 2006;55:1051–1056
  33. Pipeleers DG, Schuit FC, Van Schravendijk CF, Van de Winkel M. Interplay of nutrients and hormones in the regulation of glucagon release. Endocrinology. 1985;117:817–823
  34. Sanchez A, Hubbard RW. Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis. Med Hypotheses. 1991;36:27–32
  35. Sugano M, Ishiwaki N, Nakashima K. Dietary protein-dependent modification of serum cholesterol level in rats. Significance of the arginine/lysine ratio. Ann Nutr Metab. 1984;28:192–199
  36. Hubbard R, Kosch CL, Sanchez A, Sabate J, Berk L, Shavlik G. Effect of dietary protein on serum insulin and glucagon levels in hyper- and normocholesterolemic men. Atherosclerosis. 1989;76:55–61
  37. Palmer JP, Walter RM, Ensinck JW. Arginine-stimulated acute phase of insulin and glucagon secretion. I. in normal man. Diabetes. 1975;24:735–740

PII: S0026-0495(07)00122-9

doi: 10.1016/j.metabol.2007.04.001

Metabolism - Clinical and Experimental
Volume 56, Issue 8 , Pages 1051-1059 , August 2007

Article Tools

* Image Usage & Resolution