Metabolism - Clinical and Experimental
Volume 56, Issue 8 , Pages 1076-1080 , August 2007

Free and total leptin serum levels and soluble leptin receptors levels in two models of genetic obesity: the Prader-Willi and the Down syndromes

  • Caterina Proto

      Affiliations

    • Laboratories Department and Department of Mental Retardation, "Oasi" Institute for Research Maria SS, 94018 Troina (EN), Italy
  • ,
  • Daniela Romualdi

      Affiliations

    • Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli, 8-00168 Rome, Italy
  • ,
  • Rosa Maria Cento

      Affiliations

    • Laboratories Department and Department of Mental Retardation, "Oasi" Institute for Research Maria SS, 94018 Troina (EN), Italy
  • ,
  • Corrado Romano

      Affiliations

    • Laboratories Department and Department of Mental Retardation, "Oasi" Institute for Research Maria SS, 94018 Troina (EN), Italy
  • ,
  • Giuseppe Campagna

      Affiliations

    • Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli, 8-00168 Rome, Italy
  • ,
  • Antonio Lanzone

      Affiliations

    • Laboratories Department and Department of Mental Retardation, "Oasi" Institute for Research Maria SS, 94018 Troina (EN), Italy
    • Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli, 8-00168 Rome, Italy
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli, 8-00168 Rome, Italy. Tel.: +39 06/30577; fax: +39 06/30577.

Received 1 December 2006 ,Accepted 28 March 2007.

References 

  1. Holm VA, Cassidy BS, Butler MG, et al. Prader-Willi syndrome: consensus diagnostic criteria. Pediatrics. 1993;91:398–402
  2. Butler MG. Prader Willi syndrome: current understanding of cause and diagnosis. Am J Med Genet. 1990;35:319–332
  3. Butler MG, Palmer CG. Parental origin of chromosome. Lancet. 1983;1:285–286
  4. Swab D. Prader-Willi syndrome and the hypothalamus. Acta Pediatr (Copenh). 1997;86(suppl.):50–54
  5. Butler MG, Meaney FJ, Palmer CG. Clinical and cytogenetic survey of 39 individuals with Prader Willi syndrome. Am J Med Genet. 1986;23:793–809
  6. Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, et al. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring). 2006;14:1028–1037
  7. Hoybye C, Hilding A, Jacobsson H, Thoren M. Metabolic profile and body composition in adults with Prader-Willi syndrome and severe obesity. J Clin Endocrinol Metab. 2002;97:3590–3597
  8. Schoeller DA, Levitsky LL, Bandini LG, Dietz WW, Walezak A. Energy expenditure and body composition in Prader-Willi syndrome. Metabolism. 1988;37:115–120
  9. Brambilla P, Bosio L, Manzoni P, Pietrobelli A, Beccaria L, Chiumello G. Peculiar body composition in patients with Prader-Labhart-Willi syndrome. Am.J Clin Nutr. 1997;65:1369–1374
  10. Van Mil EA, Westertep KR, Gerver WJ, et al. Energy expenditure at rest and during sleep in children with Prader-Willi syndrome is explained by body composition. Am J Clin Nutr. 2000;71:752–756
  11. Cronk CE, Chumlea WC, Roche AF. Assessment of overweight children with trisomy 21. Am J Ment Defic. 1996;89:433–436
  12. Melville CA, Cooper SA, McGrother CW, Thorp CF, Collacott R. Obesity in adults with Down syndrome: a case-control study. J Intellect Disabil Res. 2005;49:125–133
  13. Whitt-Glover MC, O'Neill KL, Stettler N. Physical activity patterns in children with and without Down syndrome. Pedriatr Rehabil. 2006;9:158–164
  14. Allison DB, Gomez JE, Heshka S, Babbit RL, Geliebter A, Kreibich K, et al. Decreased metabolic rate among persons with Down syndrome. Int J Obes Relat Metab Disord. 1995;19:858–861
  15. O'Neill KL, Shults J, Stallings VA, Stettler N. Child-feeding practices in children with Down syndrome and their siblings. J Pediatr. 2005;146:234–238
  16. Ahima RS. Adipose tissue as an endocrine organ. Obesity (Silver Spring). 2006;14(Suppl 5):242S–249S
  17. Zhang F, Chen Y, Heinan M, Dimarchi R. Leptin: structure, function and biology. Vitam Horm. 2005;71:345–372
  18. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250–252
  19. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J, et al. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest. 1996;98:1277–1282
  20. Ogawa T, Hirose H, Yamamoto Y, Nishikai K, Miyashita K, Nakamura H, et al. Relationships between soluble serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism. 2004;53:879–885
  21. Birkenmeier G, Kämpfer I, Kratzsch J, Schellenberger W. Human leptin forms complexes with alpha 2-macroglobulin which are recognized by the alpha 2-macroglobulin receptor/low density lipoprotein receptor–related protein. Eur J Endocrinol. 1998;139:224–230
  22. Patel N, Brinkman-Van der Linden ECM, Altmann SW, Gish K, Balasubramanian S, Timans JC, et al. OB-BP1/Siglec-6: a leptin- and sialic acid–binding protein of the immunoglobulin superfamily. J Biol Chem. 1999;274:22729–22738
  23. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsh J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun. 2001;283:982–988
  24. Houseknecht KL, Mantzoros CS, Kuliwat R, Hadro E, Flier JS, Kahn BB. Evidence for leptin binding proteins in serum of rodents and humans: modulation with obesity. Diabetes. 1996;45:1638–1643
  25. Cento RM, Proto C, Spada RS, Ragusa L, Reitano S, Napolitano V, et al. Serum leptin concentrations in obese women with Down syndrome and Prader-Willi syndrome. Gynecol Endocrinol. 1999;13:36–41
  26. Weigle DS, Ganter SL, Kuijper JL, Leonetti DL, Boyko EJ, Fujimoto WY. Effect of regional fat distribution and Prader-Willi syndrome on plasma leptin levels. J Clin Endocrinol Metab. 1997;387:903–908
  27. Butler MG, Moore J, Morawiecki A, Nicolson M. Comparison of leptin protein levels in Prader-Willi syndrome and control individuals. Am J Med Genet. 1998;75:7–12
  28. Bueno G, Moreno LA, Pineda L, Campos J, Ruibal JL, Juste MG, et al. Serum leptin concentrations in children with Prader Willi syndrome and non-syndromal obesity. J Pediatr Endocrinol Metab. 2000;13:425–430
  29. Arch JR. Central regulation of energy balance: inputs, outputs and leptin resistance. Proc Nutr Soc. 2005;64:39–46
  30. Diamond FB, Eichler DC, Duckett G, Jorgensen EV, Shulman D, Root AW. Demonstration of a leptin binding factor in human serum. Biochem Biophys Res Commun. 1997;233:818–822
  31. Tartaglia LA. The leptin receptor. J Biol Chem. 1996;272:6093–6096
  32. Munzberg H, Björnholm M, Bates SH, Myers MG. Leptin receptor action and mechanism of leptin resistance. Cell Mol Life Sci. 2005;62:642–652
  33. Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem. 2001;276:6343–6349
  34. Ge H, Huang L, Pourbahrami T, Li C. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem. 2002;277:45898–45903
  35. Brabant G, Have H, Mayr B, Behrend M, Van Harmelen V, Arner P. Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women. Clin Endocrinol Metab. 2002;87:3966–3970
  36. Carmeli E, Merrick J, Kessel S, Masharawi Y, Carmeli V. Elderly persons with intellectual disability: a study of clinical characteristics, functional status, and sensory capacity. ScientificWorldJournal. 2003;3:298–307
  37. Luke A, Sutton M, Schoeller DA, Roizen NJ. Nutrient intake and obesity in prepubescent children with Down syndrome. J Am Diet Assoc. 1996;96:1262–1267
  38. Bronks R, Parker AW. Anthropometric observation of adults with Down syndrome. Am J Ment Defic. 1985;90:110–113
  39. Radunovic N, Kuczynski E, Radunovic L, Milicevic S, Funai EF, Lockwood CJ. Fetal and maternal plasma leptin levels during the second half of normal pregnancies and those with Down syndrome. J Matern Fetal Neonatal Med. 2003;13:394–397
  40. Brabant G, Horn R, Von Zur Mühlen A, Mayr B, Wurster U, Heidenreich F, et al. Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia. 2000;43:438–442
  41. Carmina E, Ferin M, Gonzalez F, Lobo RA. Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. Fertil Steril. 1999;72:926–931
  42. Messinis IE, Milingos SD, Alexandris E, Kariotis I, Kollios G, Seferiadis K. Leptin concentrations in normal women following bilateral ovariectomy. Hum Reprod. 1999;14:913–918
  43. Garcia-Mayor R, Andrade M, Rios M, Lage M, Dieguez C, Casanueva F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 1997;82:2849–2855
  44. Magni P, Ruscica M, Dozin E, Roti E, Licastro F, Motta M, et al. Free and bound leptin in prepubertal children with Down's syndrome and different degrees of adiposity. Eur J Clin Nutr. 2004;58:1547–1549
  45. Ballauff A, Ziegler A, Emons G, Sturm G, Blum WF, Remschmidt H, et al. Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain. Mol Psychiatry. 1999;4:71–75
  46. Angelopoulou N, Souftas V, Sakadamis A, Matziari C, Papameletiou V, Mandroukas K. Gonadal function in young women with Down syndrome. Int J Gynaecol Obstet. 1999;67:15–21
  47. Montague CT, Farooqii IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature. 1997;387:903–908
  48. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398–401
  49. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet. 1998;18:213–215
  50. Patel L, Cooper CD, Quinton ND, Butler GE, Gill MS, Jefferson IG, et al. Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction. J Pediatr Endocrinol Metab. 2002;15:963–971

PII: S0026-0495(07)00125-4

doi: 10.1016/j.metabol.2007.03.016

Metabolism - Clinical and Experimental
Volume 56, Issue 8 , Pages 1076-1080 , August 2007