Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus

Fukui, Michiaki; Ose, Hiroyuki; Kitagawa, Yoshihiro; Yamazaki, Masahiro; Hasegawa, Goji; Yoshikawa, Toshikazu; Nakamura, Naoto

doi:10.1016/j.metabol.2007.04.011

« Previous Next »Metabolism - Clinical and Experimental
Volume 56, Issue 9 , Pages 1167-1173, September 2007

Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus

Michiaki Fukui
- Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
- Corresponding author. Tel.: +81 75 251 5505; fax: +81 75 252 3721.
Hiroyuki Ose
- Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Yoshihiro Kitagawa
- Department of Endocrinology and Hematology, Osaka General Hospital of West Japan Railway Company, Osaka 545-0053, Japan
Masahiro Yamazaki
- Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Goji Hasegawa
- Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Toshikazu Yoshikawa
- Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan
Naoto Nakamura
- Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan

Received 30 September 2006; accepted 2 April 2007.

Abstract

The aim of this study was to evaluate the relationship between arterial stiffness determined by pulse wave velocity (PWV) and serum endogenous androgen concentrations as well as major cardiovascular risk factors in men with type 2 diabetes mellitus. Serum free testosterone and dehydroepiandrosterone sulfate (DHEA-S) concentrations were measured in 268 men with type 2 diabetes mellitus. Relationships between PWV and serum endogenous androgen concentrations as well as major cardiovascular risk factors, including age, blood pressure, serum lipid concentration, glycemic control (hemoglobin A_1c), body mass index, and degree of albuminuria, were evaluated. Positive correlations were found between PWV and age (r = 0.491, P < .0001), duration of diabetes (r = 0.320, P < .0001), systolic blood pressure (r = 0.292, P < .0001), and log (urinary albumin excretion) (r = 0.269, P < .0001). Inverse correlations were found between serum free testosterone concentration and PWV (r = −0.228, P = .0003) and between serum DHEA-S concentration and PWV (r = −0.252, P = .0002) in men with type 2 diabetes mellitus. Pulse wave velocity was significantly greater in patients with lower concentrations of free testosterone (<10 pg/mL) than in patients with higher concentrations of free testosterone (1864 ± 359 vs 1736 ± 327 cm/s; P = .0053). Pulse wave velocity also was significantly greater in patients with lower concentrations of DHEA-S (<1000 ng/mL) than in patients with higher concentrations of DHEA-S (1843 ± 371 vs 1686 ± 298 cm/s; P = .0008). Multiple regression analysis identified both serum free testosterone concentration (β = −.151, P = .0150) and serum DHEA-S concentration (β = −.200, P = .0017) as independent determinants of PWV. In conclusion, serum endogenous androgen concentrations are inversely associated with arterial stiffness determined by PWV in men with type 2 diabetes mellitus, which is true for men in general based on other works.