Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach

Received 18 September 2007; accepted 15 January 2008.

Abstract

Randomized studies in early-maturing (P2 <8 years, B2 between 8 and 9 years), low–birth weight girls (N = 60) show that calorie restriction mimetic therapy with metformin for 3 years is accompanied by a strikingly leaner body composition (on average, 5.2 kg less gain of fat; 1.6 kg more gain of lean mass; P < .0001).

a Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, 08950 Esplugues, Barcelona, Spain

b Diabetes, Endocrinology and Nutrition Unit, Dr Trueta Hospital, 17007 Girona, Spain

c Department of Woman and Child, University of Leuven, 3000 Leuven, Belgium

Corresponding author. Tel.: +34 93 2804000x2261; fax: +34 93 2033959.

PII: S0026-0495(08)00035-8

doi:10.1016/j.metabol.2008.01.002

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