Preliminary report: A serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population
Received 11 February 2009; accepted 31 July 2009. published online 01 October 2009.
Abstract
This large-scale cross-sectional investigation highlights the relationships between adiponectin levels and a number of metabolic syndrome components in a nondiabetic Korean population (N = 6634). In a multivariate logistic regression model, after adjustment for age, homeostasis model assessment of insulin resistance, body mass index, smoking history, C-reactive protein, and low-density lipoprotein cholesterol, adiponectin levels were inversely related with metabolic syndrome in men and women (P < .05). Adiponectin level was found to be a significant contributor to metabolic syndrome. Our findings suggest that adiponectin is an important biomarker even in a nondiabetic population at high risk of metabolic syndrome.
aDepartment of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea
bInstitute of Genomic Cohort, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea
cInstitute of Life-Long Health, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea
dInstitute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea
eDepartment of Cardiology, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea
fDepartment of Preventive Medicine, College of Medicine, Chosun University, Gwangju 501-759, South Korea
gDepartment of Preventive Medicine, College of Medicine, Chungnam National University, DaeJeon 301-747, South Korea
hDepartment of Physical Therapy, Yonsei University 220-710, Wonju, South Korea
Corresponding authors. Joshua H. You is to be contacted at Department of Physical Therapy, Graduate School of Rehabilitation Science, Yonsei University, Director of Center for Movement Impairment Solutions; Center for Health, Wellness, Fitness, Prevention, and Healing Across the Life Span, MaeJi-Ri, Wonju City, Kangwon-do 220-710, Republic of South Korea. Tel.: +82 033 760 2476; fax: +82 033 760 2496. Jong-Ku Park, MD, Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju City, Kangwon-do 220-701, Republic of S Korea. Tel.: +82 033 741 0342; fax: +82 033 747 0409.
ABSTRACT