Metabolism - Clinical and Experimental
Volume 59, Issue 5 , Pages 635-644, May 2010

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway

  • Eliane Filiputti

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Alex Rafacho

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • Present address: Department of Physical Education, School of Sciences, São Paulo State University (UNESP), CEP 13033-360 Bauru, SP, Brazil.
    • ,
  • Eliana P. Araújo

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Leonardo R. Silveira

      Affiliations

    • School of Physical Education and Sports, University of Sao Paulo (USP), CEP 14040-900 Ribeirão Preto, SP, Brazil
    • ,
  • Amon Trevisan

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Thiago M. Batista

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Rui Curi

      Affiliations

    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), CEP 05508-900 São Paulo, SP, Brazil
    • ,
  • Lício A. Velloso

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Ivan Quesada

      Affiliations

    • CIBERDEM and Institute of Bioengineering, University of Miguel Hernández, CEP 03202 Elche, Spain
    • ,
  • Antonio C. Boschero

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • ,
  • Everardo M. Carneiro

      Affiliations

    • Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), CEP 13083-970 Campinas, SP, Brazil
    • National Institute of Obesity and Diabetes, CEP 13083-970 Campinas, SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 19 3521 6203; fax: +55 19 3521 6185.

Received 23 April 2009; accepted 4 September 2009. published online 16 November 2009.

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 The authors declare that there is no conflict of interest that would prejudice the impartiality of this scientific work.

 The experiments with animals are in adherence with the institutional State University of Campinas Committee for Ethics in Animal Experimentation.

PII: S0026-0495(09)00381-3

doi:10.1016/j.metabol.2009.09.007

Metabolism - Clinical and Experimental
Volume 59, Issue 5 , Pages 635-644, May 2010

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