Metabolism - Clinical and Experimental
Volume 59, Issue 5 , Pages 711-717, May 2010

A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation

  • Alberto Penas Steinhardt

      Affiliations

    • Humoral Immunity Institute “Prof Ricardo A. Margni” (IDEHU), National Research Council (CONICET) and School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), 1113 Buenos Aires, Argentina
    • ,
  • Florencia Aranguren

      Affiliations

    • Division of Diabetology, Clinical Hospital “José de San Martín,” University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • ,
  • Mariana L. Tellechea

      Affiliations

    • Laboratory of Molecular Biology, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • ,
  • Leonardo A. Gómez Rosso

      Affiliations

    • Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA) and National Research Council (CONICET), 1120 Buenos Aires, Argentina
    • ,
  • Fernando D. Brites

      Affiliations

    • Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA) and National Research Council (CONICET), 1120 Buenos Aires, Argentina
    • ,
  • Maria T. Martínez-Larrad

      Affiliations

    • Department of Internal Medicine II, Hospital Clínico San Carlos, 28040 Madrid, Spain
    • ,
  • Manuel Serrano-Ríos

      Affiliations

    • Department of Internal Medicine II, Hospital Clínico San Carlos, 28040 Madrid, Spain
    • ,
  • Gustavo D. Frechtel

      Affiliations

    • Laboratory of Molecular Biology, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • Division of Genetics, Clinical Hospital “José de San Martín,” University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • GDF and MJT contributed equally to this work.
    • ,
  • Mariano J. Taverna

      Affiliations

    • Humoral Immunity Institute “Prof Ricardo A. Margni” (IDEHU), National Research Council (CONICET) and School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), 1113 Buenos Aires, Argentina
    • Division of Diabetology, Clinical Hospital “José de San Martín,” University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • Division of Genetics, Clinical Hospital “José de San Martín,” University of Buenos Aires (UBA), 1120 Buenos Aires, Argentina
    • Corresponding Author InformationCorresponding author.
    • GDF and MJT contributed equally to this work.

Received 1 April 2009; accepted 16 September 2009. published online 19 November 2009.

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 Conflicts of interest/disclosure statement: The authors have nothing to disclose.

 Institutional approval: This study was carried out in accordance with the Declaration of Helsinki and was approved by the ethics committee of our institution.

PII: S0026-0495(09)00405-3

doi:10.1016/j.metabol.2009.09.015

Metabolism - Clinical and Experimental
Volume 59, Issue 5 , Pages 711-717, May 2010

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