Metabolism - Clinical and Experimental
Volume 59, Issue 9 , Pages 1241-1251, September 2010

Adipose tissue–specific dysregulation of angiotensinogen by oxidative stress in obesity

  • Sadanori Okada

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • First Department of Internal Medicine, Nara Medical University, Kashihara 634-8522, Japan
    • Sadanori Okada and Chisayo Kozuka contributed equally to this work.
    • ,
  • Chisayo Kozuka

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • Sadanori Okada and Chisayo Kozuka contributed equally to this work.
    • ,
  • Hiroaki Masuzaki

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • Corresponding Author InformationCorresponding author. Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan. Tel.: +81 98 895 1145; fax: +81 98 895 1415.
    • ,
  • Shintaro Yasue

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Takako Ishii-Yonemoto

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Tomohiro Tanaka

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Yuji Yamamoto

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Michio Noguchi

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Toru Kusakabe

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Tsutomu Tomita

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Junji Fujikura

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Ken Ebihara

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Kiminori Hosoda

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    • ,
  • Hiroshi Sakaue

      Affiliations

    • Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan
    • ,
  • Hiroyuki Kobori

      Affiliations

    • Departments of Medicine and Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA
    • ,
  • Mira Ham

      Affiliations

    • Institute of Molecular Biology and Genetics, Seoul National University, Seoul 110-744, South Korea
    • ,
  • Yun Sok Lee

      Affiliations

    • Institute of Molecular Biology and Genetics, Seoul National University, Seoul 110-744, South Korea
    • ,
  • Jae Bum Kim

      Affiliations

    • Institute of Molecular Biology and Genetics, Seoul National University, Seoul 110-744, South Korea
    • ,
  • Yoshihiko Saito

      Affiliations

    • First Department of Internal Medicine, Nara Medical University, Kashihara 634-8522, Japan
    • ,
  • Kazuwa Nakao

      Affiliations

    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan

Received 27 August 2009; accepted 18 November 2009. published online 04 January 2010.

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 The authors of this manuscript have nothing to declare.

 Institutional approval: The human study was approved by the ethics committee for human research of the Kyoto University Graduate School of Medicine (2004, no. 553). Written informed consent was obtained from all subjects prior to the study. All animal experimental procedures were approved by the Kyoto University Graduate School of Medicine Animal Research Committee and the Seoul National University Animal Experiment Ethics Committee.

PII: S0026-0495(09)00491-0

doi:10.1016/j.metabol.2009.11.016

Metabolism - Clinical and Experimental
Volume 59, Issue 9 , Pages 1241-1251, September 2010

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