Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects

Chang, Hye Mi; Park, Hye Soon; Park, Cheol-Young; Song, Young Sook; Jang, Yeon Jin

doi:10.1016/j.metabol.2009.11.021

« Previous Next »Metabolism - Clinical and Experimental
Volume 59, Issue 9 , Pages 1276-1281, September 2010

Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects

Hye Mi Chang
- Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea
Hye Soon Park
- Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea
- Corresponding author. Hye Soon Par is to be contacted at Department of Family Medicine, University of Ulsan College of Medicine 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea. Tel.: +82 2 3010 3813; fax: +82 2 3010 3815. Yeon Jin Jang Department of Physiology, University of Ulsan College of Medicine 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea. Tel.: +82 2 3010 4274; fax: +82 2 3010 8029.
Cheol-Young Park
- Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Young Sook Song
- Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea
Yeon Jin Jang
- Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea
- Corresponding author. Hye Soon Par is to be contacted at Department of Family Medicine, University of Ulsan College of Medicine 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea. Tel.: +82 2 3010 3813; fax: +82 2 3010 3815. Yeon Jin Jang Department of Physiology, University of Ulsan College of Medicine 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea. Tel.: +82 2 3010 4274; fax: +82 2 3010 8029.

Received 25 August 2009; accepted 27 November 2009. published online 08 January 2010.

Abstract

Adipokines modulate multiple signaling pathways of insulin resistance via endocrine, paracrine, or autocrine mechanisms. Visceral adipose tissue (VAT)–derived serpin (vaspin) is a novel adipokine with potential insulin-sensitizing effects. We investigated the association between serum vaspin concentrations and abdominal adiposity. We recruited subjects (N = 150) aged 20 to 69 years who visited our hospital for regular health examinations. Abdominal VAT and subcutaneous adipose tissue areas were assessed by computed tomography. We measured serum vaspin concentrations by enzyme-linked immunosorbent assay. Statistical analysis was performed after stratification, using a homeostasis model for insulin resistance (HOMA-IR). Serum vaspin concentrations correlated positively with age (r = 0.196) when data from all subjects were analyzed. In the higher–HOMA-IR group, serum vaspin levels correlated more prominently with age (r = .344) and VAT area (r = .327) although these associations were not found in the lower–HOMA-IR group. In multivariate linear regression analysis, the VAT area was independently correlated with serum vaspin concentrations in the higher–HOMA-IR group. The association between serum vaspin concentrations and VAT differs according to insulin resistance. Insulin resistance might influence the correlation between serum vaspin concentration and VAT in human subjects.