Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

Olofsson, Louise E.; Olsson, Bob; Lystig, Theodore; Jacobson, Peter; Jernås, Margareta; Sjöholm, Kajsa; Gummesson, Anders; Sjöström, Lars; Eriksson, Per; Hamsten, Anders; Hale, Laura P.; Thelle, Dag S.; Carlsson, Björn; Carlsson, Lena M.S.

doi:10.1016/j.metabol.2009.12.006

« Previous Next »Metabolism - Clinical and Experimental
Volume 59, Issue 9 , Pages 1316-1318, September 2010

Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

Louise E. Olofsson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
- Both of these authors contributed equally.
Bob Olsson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
- Corresponding author. Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden. Tel.: +46 31 342 32 03; fax: +46 31 41 85 27.
- Both of these authors contributed equally.
Theodore Lystig
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Peter Jacobson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Margareta Jernås
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Kajsa Sjöholm
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Anders Gummesson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Lars Sjöström
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Per Eriksson
- Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
Anders Hamsten
- Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
Laura P. Hale
- Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Dag S. Thelle
- Department of Biostatistics, Institute of Basic Medical Science, University of Oslo, 0317 Oslo, Norway
Björn Carlsson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Lena M.S. Carlsson
- The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden

Received 31 August 2009; accepted 2 December 2009. published online 13 January 2010.

Abstract

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.