Metabolism - Clinical and Experimental
Volume 60, Issue 5 , Pages 655-663, May 2011

The APOE −219G/T and +113G/C polymorphisms affect insulin resistance among Turks

  • Evrim Komurcu-Bayrak

      Affiliations

    • Department of Genetics, Institute for Experimental Medicine, Istanbul University, 34080, Istanbul, Turkey
    • Corresponding Author InformationCorresponding author.
    • ,
  • Altan Onat

      Affiliations

    • Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, 34099, Istanbul, Turkey
    • ,
  • Berna Yuzbasiogullari

      Affiliations

    • Department of Genetics, Institute for Experimental Medicine, Istanbul University, 34080, Istanbul, Turkey
    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Medical School, 33521, Tampere, Finland
    • ,
  • Nina Mononen

      Affiliations

    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Medical School, 33521, Tampere, Finland
    • ,
  • Reijo Laaksonen

      Affiliations

    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Medical School, 33521, Tampere, Finland
    • ,
  • Mika Kähönen

      Affiliations

    • Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Medical School, 33521, Tampere, Finland
    • ,
  • Gulay Hergenc

      Affiliations

    • Department of Biology, Yildiz Technical University, 34349, Istanbul, Turkey
    • ,
  • Terho Lehtimäki

      Affiliations

    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Medical School, 33521, Tampere, Finland
    • ,
  • Nihan Erginel-Unaltuna

      Affiliations

    • Department of Genetics, Institute for Experimental Medicine, Istanbul University, 34080, Istanbul, Turkey

Received 26 March 2010; accepted 22 June 2010. published online 19 August 2010.

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 Study subjects were unrelated and gave written consent to participate in the study after being informed of its nature. The study protocol was approved by the Ethics Committee of the Istanbul Medical Faculty, Istanbul University.

 EKB wrote the manuscript, carried out the experimental work, and performed the statistical analyses; AO initiated the study and participated in its design as well as the coordination and collection of clinical data, in addition to editing the manuscript; BY and NM assisted in planning the study and participated in the experimental work; RL and MK assisted in planning the study and drafting the manuscript; GH carried out the biochemical experimental work and edited the manuscript; TL and NEU were responsible for the molecular genetic studies and participated in planning the study and drafting the manuscript.

PII: S0026-0495(10)00203-9

doi:10.1016/j.metabol.2010.06.016

Metabolism - Clinical and Experimental
Volume 60, Issue 5 , Pages 655-663, May 2011

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