Metabolism - Clinical and Experimental
Volume 45, Issue 6 , Pages 669-672, June 1996

Preliminary report The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease☆

  • Gary Frost

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Gary Frost, BSc, Nutrition and Dietetic Department, Hammersmith Hospital, London W12 OHS, UK.
    • ,
  • Bruce Keogh

      Affiliations

    • Department of Nutrition and Dietetics, Hammersmith Hospital, and the Department of Endocrinology and Metabolism and the Cardiothoracic Surgical Unit, Royal Postgraduate Medical School, London UK
    • Department of Nutrition and Dietetics, Kings College, University of London, London, UK
    • ,
  • David Smith

      Affiliations

    • Department of Nutrition and Dietetics, Hammersmith Hospital, and the Department of Endocrinology and Metabolism and the Cardiothoracic Surgical Unit, Royal Postgraduate Medical School, London UK
    • Department of Nutrition and Dietetics, Kings College, University of London, London, UK
    • ,
  • Karen Akinsanya

      Affiliations

    • Department of Nutrition and Dietetics, Hammersmith Hospital, and the Department of Endocrinology and Metabolism and the Cardiothoracic Surgical Unit, Royal Postgraduate Medical School, London UK
    • Department of Nutrition and Dietetics, Kings College, University of London, London, UK
    • ,
  • Anthony Leeds

      Affiliations

    • Department of Nutrition and Dietetics, Hammersmith Hospital, and the Department of Endocrinology and Metabolism and the Cardiothoracic Surgical Unit, Royal Postgraduate Medical School, London UK
    • Department of Nutrition and Dietetics, Kings College, University of London, London, UK

Received 27 June 1995; accepted 4 December 1995.

Abstract 

The insulin resistance syndrome has recently been implicated in the etiology of coronary heart disease, with a possible metabolic defect at the level of the adipocyte. We report the effects of a low— versus high—glycemic-index (LGI and HGI, respectively) diet on insulin and glucose response as assessed by oral glucose tolerance test (OGTT) and insulin-stimulated glucose uptake in isolated adipocytes in a group of 32 patients with advanced coronary heart disease. The area under the insulin curve following OGTT was significantly reduced after 4 weeks in the LGI group (P < .03), but not in the HGI group. Insulin-stimulated glucose uptake in isolated adipocytes harvested from a presternal fat biopsy was significantly greater following the LGI diet (P < .05). This study demonstrates that simple short-term dietary measures can improve insulin sensitivity in patients with coronary heart disease.

No full text is available. To read the body of this article, please view the PDF online.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ Supported by British Heart Foundation Project Grant No. PG93/145. Gary Frost is in receipt of a bursary from Kelloggs UK.

PII: S0026-0495(96)90129-8

Metabolism - Clinical and Experimental
Volume 45, Issue 6 , Pages 669-672, June 1996

Article Tools