Metabolism - Clinical and Experimental
Volume 45, Issue 6 , Pages 707-711, June 1996

Increased sodium influx and calcium uptake in erythrocytes in hyperthyroidism: Role of abnormal membrane lipid levels

Department of Endocrinology, Umberto Io General Hospital, Mestre-Venice, Italy.

Received 6 February 1995; accepted 4 December 1995.

Abstract 

The study was designed to examine the effects of thyroid hormones on red blood cell (RBC) membrane phospholipids and ion transport. We demonstrated that in untreated Graves' disease, an alteration in the phospholipid pattern is present at cellular levels, with a concomitant derangement in membrane permeability defined as 22Na influx and 45Ca uptake. Thionamide therapy replaced the normal membrane permeability, presumably as a consequence of restoring the normal phospholipid membrane composition. We conclude that thyroid hormones are able to induce a quick breakdown of a large number of membrane components such as membrane phospholipids.

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PII: S0026-0495(96)90135-3

Metabolism - Clinical and Experimental
Volume 45, Issue 6 , Pages 707-711, June 1996

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