Metabolism - Clinical and Experimental
Volume 45, Issue 1 , Pages 28-33, January 1996

Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats☆

  • Yoshifumi Noguchi

      Affiliations

    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA
    • ,
  • Tory A. Meyer

      Affiliations

    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA
    • ,
  • Greg Tiao

      Affiliations

    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA
    • ,
  • Cora K. Ogle

      Affiliations

    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA
    • ,
  • Josef E. Fischer

      Affiliations

    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA
    • ,
  • Per-Olof Hasselgren

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Per-Olof Hasselgren, MD, Department of Surgery, University of Cincinnati, 231 Bethesda Ave (ML #558), Cincinnati, OH 45267-0558.
    • Department of Surgery, University of Cincinnati, Cincinnati USA
    • Shriners Bums Institute, Cincinnati, OH USA

Received 23 September 1994; accepted 13 July 1995.

Abstract 

We examined the influence of sepsis and endotoxemia in rats on the biosynthesis of polyamines in small-intestinal mucosa. Sepsis was induced by cecal ligation and puncture (CLP); control rats were sham-operated. In other experiments, rats were treated with two subcutaneous injections of endotoxin (1 mg/kg) or corresponding injections of sterile saline. Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities and concentrations of putrescine, spermidine, and spermine were measured in jejunal mucosa at intervals during 16 hours. Sepsis stimulated ODC and SAMDC activities and increased putrescine and spermidine concentrations in jejunal mucosa. Injection of endotoxin resulted in metabolic changes similar to those observed following CLP. The results suggest that sepsis and endotoxemia stimulate polyamine biosynthesis in mucosa of small intestine. The role of polyamines in the regulation of cell proliferation and metabolic changes in the intestinal mucosa during sepsis remains to be determined.

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☆ Supported in part by National Institutes of Health Grant No. DK 44201 and Grant No. 15851 from Shriners of North America.

PII: S0026-0495(96)90196-1

Metabolism - Clinical and Experimental
Volume 45, Issue 1 , Pages 28-33, January 1996

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