Hepatic iron overload may contribute to hypertriglyceridemia and hypercholesterolemia in copper-deficient rats

Abstract 

The present study was conducted in order to determine whether hepatic iron retention in rats fed a copper-deficient diet containing fructose is associated with hypertriglyceridemia and hypercholesterolemia, and whether a reduction of iron intake will prevent elevation of blood triglycerides and cholesterol. Rats were fed from weaning either a copper-deficient (0.6 μg Cu/g) or copper-adequate (6.0 μg Cu/g) diet for 4 weeks. Half the rats consumed either an adequate level of iron (50 μg Fe/g) or a low level (17 μg Fe/g). Reduction of iron intake reduced blood levels of both triglycerides and cholesterol in rats fed a copper-deficient diet containing fructose. In addition, hepatic lipid peroxidation was also decreased. The combination of high iron, low copper, and fructose may be responsible for increased levels of risk-factor metabolites associated with heart disease.

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