Polymorphism of the glycogen synthase gene and non—insulin-dependent diabetes mellitus in the Russian population

Babadjanova, Gulja; Allolio, Bruno; Beuschlein, Felix; Chuchalin, Alexander; Reincke, Martin

Next »Metabolism - Clinical and Experimental
Volume 46, Issue 2 , Pages 121-122, February 1997

Polymorphism of the glycogen synthase gene and non—insulin-dependent diabetes mellitus in the Russian population☆

Gulja Babadjanova
- Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Germany
- Department of Internal Medicine, Moscow State Medical University, Moscow, Russia
Bruno Allolio
- Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Germany
- Department of Internal Medicine, Moscow State Medical University, Moscow, Russia
Felix Beuschlein
- Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Germany
- Department of Internal Medicine, Moscow State Medical University, Moscow, Russia
Alexander Chuchalin
- Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Germany
- Department of Internal Medicine, Moscow State Medical University, Moscow, Russia
Martin Reincke
- Address reprint requests to Martin Reincke, MD, Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany.
- Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg, Germany
- Department of Internal Medicine, Moscow State Medical University, Moscow, Russia

Received 14 May 1996; accepted 20 August 1996.

Abstract

Recently, a polymorphism in the glycogen synthase gene was shown to be associated with the development of non-insulin dependent diabetes mellitus (NIDDM) and identified patients with a strong family history of diabetes and hypertension in the Finnish population. However, no association was found in French and Japanese populations. We investigated the possible association between the Xbal polymorphism of the glycogen synthase gene and NIDDM in the Russian population. One hundred fifty NIDDM patients and 109 healthy controls were studied. In 16 of 150 Russian NIDDM patients (10.7%), the Xbal polymorphism was found, and 17 of 109 controls (15.6%) showed the Xbal polymorphism (P > .05). These results suggest that the Xbal polymorphism of the glycogen synthase gene cannot be used as a marker for NIDDM in the Russian population.

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