Metabolism - Clinical and Experimental
Volume 46, Issue 2 , Pages 146-148, February 1997

Characterization of low-density lipoprotein subclasses in children☆☆☆

  • Osamu Arisaka

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Osamu Arisaka, MD, Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Sachi Fujiwara

      Affiliations

    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Keijiro Yabuta

      Affiliations

    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Mokuno

      Affiliations

    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Yasushi Mitugi

      Affiliations

    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Noriko Miyake

      Affiliations

    • Departments of Pediatrics, Divisions of Cardiology, Internal Medicine, Tokyo, Japan
    • Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan

Received 31 December 1995; accepted 13 September 1996.

Abstract 

Low-density lipoprotein (LDL) particles are heterogeneous in density, size, and chemical composition, and this heterogeneity is thought to be genetically influenced. In the present study, plasma LDL subclasses in 248 children aged 7 to 13 years were analyzed by gradient gel electrophoresis. The prevalence of small dense LDL (SDLDL), a potent atherogenic LDL, was 9.3%, which is lower than that reported in adults. Furthermore, children with this LDL subclass showed increased body fatness and dyslipidemia, including elevated plasma triglyceride and apolipoprotein (apo) B concentrations and decreased plasma high-density lipoprotein (HDL) cholesterol and apo A-I concentrations, compared with children without this phenotype. These findings suggest that in addition to genetic factors, environmental factors that affect these cardiovascular risk factors may also influence expression of the SDLDL subclass.

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☆ Supported by grants from the National Ministry of Health and Welfare (Research Task for the Establishment of Healthy Life-Style From Childhood) and the National Ministry of Education (06670828).

☆☆ Presented at the 28th and 29th Annual Meetings of the Japanese Society for Pediatric Endocrinology, Chiba, Japan, October 6, 1994, and Okayama, Japan, November 9, 1995.

PII: S0026-0495(97)90292-4

Metabolism - Clinical and Experimental
Volume 46, Issue 2 , Pages 146-148, February 1997

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