Metabolism - Clinical and Experimental
Volume 47, Issue 6 , Pages 627-629, June 1998

Glucose-6-phosphatase activity in the hypothalamus of the mouse☆

  • Akhtar Khan

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Akhtar Khan, PhD, Department of Molecular Medicine, Endocrine and Diabetic Unit, Karolinska Hospital, 171 76 Stockholm, Sweden.
    • Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    • Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    • ,
  • Ling Zong-Chao

      Affiliations

    • Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    • Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    • ,
  • Suad Efendic

      Affiliations

    • Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    • Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    • ,
  • Bernard R. Landau

      Affiliations

    • Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    • Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH, USA

Received 6 August 1997; accepted 23 December 1997.

Abstract 

The hypothalamus and cortex from mice and their lean littermates were sonicated and then incubated with glucose-6-phosphate (glucose-6-P) and glycerol phosphate (glycerol-P). The difference between the rates of hydrolysis of glucose-6-P and glycerol-P was taken as the measure of glucose-6-phosphatase activity. The activity was much higher in the hypothalamus from mice versus their lean littermates. Activity was undetected in the cortex. These findings raise the possibility that a defect in the regulation of glucose-6-phosphatase activity in a portion of the hypothalamus may relate to the mechanism underlying obesity in the mouse. However, obese gene product administration to mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity.

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☆ Supported by grants from the Swedish Medical Research Council (00034), Eli Lilly & Co (Indianapolis, IN), and the National Institutes of Health (DK-14507), and a Fogarty International Center Senior Fellowship Award (TW 01986).

PII: S0026-0495(98)90021-X

Metabolism - Clinical and Experimental
Volume 47, Issue 6 , Pages 627-629, June 1998

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