Metabolism - Clinical and Experimental
Volume 47, Issue 6 , Pages 686-689, June 1998

Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects☆

  • Vivian A. Fonseca

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Vivian A. Fonseca, MD, VA Medical Center, 4300 W 7th St, Little Rock, AR 72205.
    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA
    • ,
  • Sunder Mudaliar

      Affiliations

    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA
    • ,
  • B. Schmidt

      Affiliations

    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA
    • ,
  • Louis M. Fink

      Affiliations

    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA
    • ,
  • Philip A. Kern

      Affiliations

    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA
    • ,
  • Robert R. Henry

      Affiliations

    • Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA
    • University of California at San Diego and Veterans Administration Hospital, San Diego, CA, USA

Received 10 July 1997; accepted 31 December 1997.

Abstract 

An association between hyperhomocysteinemia and premature atherosclerosis in patients with non—insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine [H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 ± 2.6 to 6.0 ± 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 ± 2.7 to 5.9 ± 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin-resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.

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☆ Supported in part by a grant from the Arkansas Affiliate of the American Heart Association.

PII: S0026-0495(98)90031-2

Metabolism - Clinical and Experimental
Volume 47, Issue 6 , Pages 686-689, June 1998

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