Metabolism - Clinical and Experimental
Volume 47, Issue 5 , Pages 560-565, May 1998

Lack of interaction of apolipoprotein E phenotype with the lipoprotein response to lovastatin or gemfibrozil in patients with primary hypercholesterolemia☆

  • Carolina Sanllehy

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Elena Casals

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Camino Rodriguez-Villar

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Daniel Zambón

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Julia Ojuel

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Antonio M. Ballesta

      Affiliations

    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain
    • ,
  • Emilio Ros

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Emilio Ros, MD, Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Villarroel 170, Barcelona E-08036, Spain.
    • Clinical Biochemistry Department and the Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Barcelona, Spain
    • Statistics Department, University of Barcelona Medical School, Barcelona, Spain

Received 24 May 1997; accepted 13 November 1997.

Abstract 

The magnitude of serum lipid changes in response to hypolipidemic drugs varies considerably between individuals. These differences may be due to interactions between genetic and environmental factors that effect drug bioavailability or the capacity of the lipid-regulating enzyme and receptor targets to be affected. The apolipoprotein E (apoE) gene locus has been examined in this regard, but reports are conflicting on the effect of its variability on the response to hypolipidemic drugs. We investigated the effect of apoE polymorphism on the serum lipid response to the hepatic hydroxymethyl glutaryl coenzyme A (HMG CoA) reductase inhibitor lovastatin and the fibric acid derivative gemfibrozil. Lipoprotein changes were assessed after 12 weeks of therapy in 106 patients with primary hypercholesterolemia and combined hyperlipidemia treated with lovastastin and in 63 given gemfibrozil therapy. No significant effect of the apoE phenotypes E3/2, E3/3, or E4/3 on the heterogeneity of lipid responses to either drug was found.

No full text is available. To read the body of this article, please view the PDF online.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ Supported in part by Grant No. 90/0756 from Fondo de Investigaciones Sanitarias, Spanish Ministry of Health, and grants from the Fundació Clínic per la Recerca Biomédica and Fundació Privada Catalana de Nutrició i Lípids.

PII: S0026-0495(98)90240-2

Metabolism - Clinical and Experimental
Volume 47, Issue 5 , Pages 560-565, May 1998

Article Tools