Metabolism - Clinical and Experimental
Volume 47, Issue 10 , Pages 1174-1179, October 1998

Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: The insulin resistance atherosclerosis study☆

  • Barbara V. Howard

      Affiliations

    • Corresponding Author InformationAddess reprint requests to Barbara V. Howard, PhD, Medlantic Research Institute, 108 Irving St NW, Washington, DC 20010-2933.
    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Elizabeth J. Mayer-Davis

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • David Goff

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Daniel J. Zaccaro

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Ami Laws

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • David C. Robbins

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Mohammad F. Saad

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Joseph Selby

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Richard F. Hamman

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Ronald M. Krauss

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA
    • ,
  • Steven M. Haffner

      Affiliations

    • Medlantic Research Institute, Washington, DC, USA
    • Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA
    • Department of Medicine, Stanford Medical School, Palo Alto, CA, USA
    • Department of Medicine, University of Southern California Medical School, Los Angeles, CA, USA
    • Division of Research, Kaiser Permanente, Oakland, CA, USA
    • Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    • Lawrence Berkeley Laboratory, University of California, Donner Laboratories, Berkeley, CA, USA
    • University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA

Received 16 April 1997; accepted 29 April 1998.

Abstract 

The study purpose was to explore the association between dyslipidemia and insulin resistance in three ethnic groups. The Insulin Resistance Atherosclerosis Study (IRAS) is a multicenter epidemiologic study conducted at four clinical centers in California, Texas, and Colorado. The study population for this analysis consisted of 931 non-Hispanic white, African American, and Hispanic men and women (aged 45 to 64 years) without diabetes. The IRAS clinical examinations included lipoprotein measures, a 75-g glucose tolerance test, and the frequently sampled intravenous glucose tolerance (FSIGT) test. The results show a consistent relationship between insulin-mediated glucose disposal and dyslipidemia in African American, Hispanic, and non-Hispanic white men and women. Further, LDL size was inversely associated with insulin resistance in all three ethnic groups. These findings indicate ethat dyslipidemia is a fundamental part of the insulin resistance syndrome in all of the ethnic groups studied.

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☆ Supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NHLBI Grants No. HL47887, HL47889, HL47890, HL47892, and HL47902) and by the General Clinical Research Centers Program (M01 RR431 and M01 RR01346).

PII: S0026-0495(98)90319-5

Metabolism - Clinical and Experimental
Volume 47, Issue 10 , Pages 1174-1179, October 1998

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