Metabolism - Clinical and Experimental
Volume 47, Supplement 1 , Pages 3-6, December 1998

Pathophysiology of diabetic nephropathy

  • Mark E. Cooper

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Mark E. Cooper, MD, PhD, Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre (Repatriation Campus), West Heidelberg, Vic, Australia 3081.
    • Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia
    • Nephrology Section, Veterans Affairs Medical Center, University of Miami, Miami, FL, USA
    • ,
  • Richard E. Gilbert

      Affiliations

    • Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia
    • Nephrology Section, Veterans Affairs Medical Center, University of Miami, Miami, FL, USA
    • ,
  • Murray Epstein

      Affiliations

    • Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia
    • Nephrology Section, Veterans Affairs Medical Center, University of Miami, Miami, FL, USA

Abstract 

Diabetic nephropathy (DN) is now the commonest cause of end-stage renal failure in the Western world. Recent studies examining the pathogenesis of diabetic complications have focused on the complex interaction between genetic and hemodynamic mechanisms in addition to metabolic factors such as advanced glycation, protein kinase C (PKC) activation, and polyol production. The importance of the various components, particularly with regard to the progression of DN, is currently being explored with the assistance of targeted drug intervention studies.

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PII: S0026-0495(98)90362-6

Metabolism - Clinical and Experimental
Volume 47, Supplement 1 , Pages 3-6, December 1998

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