Research Article| Volume 13, ISSUE 3, P195-204, March 1964

Calories do count

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      There have been statements in the medical and the lay literature to the effect that weight loss occurs more rapidly with diets high in fat and protein asc compared to equi-caloric diets containing large amounts of carbohydrate. In the present study, subjects have been maintained for many weeks on constant calorie intake. At intervals, the composition of the diet has been changed, the fat intake varying from 12 to 83 per cent, protein from 14 to 36 per cent, and carbohydrate from 3 to 64 per cent of total calories. In any given subject, the rate of weight loss was essentially constant throughout the entire study. It is therefore obvious that the significant factor responsible for weight loss is reduction of calories, irrespective of the composition of the diet.
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        • Pennington A.W.
        The use of fat in a weight reducing diet.
        Delaware State Med. J. 1951; 23: 79
        • Pennington A.W.
        Pyruvic acid metabolism in obesity.
        Am. J. Digest Dis. 1955; 22: 33
        • Keckwick A.
        • Pawan G.L.S.
        Caloric intake in relation to body weight changes in the obese.
        Lancet. 1956; 2: 155
        • Keckwick A.
        • Pawan G.L.S.
        Metabolic study in human obesity with iso-caloric diets high in fat, protein and carbohydrate.
        Metabolism. 1957; 6: 447
        • Michaels G.D.
        A method for the determination of glycerides and free fatty acids.
        Metabolism. 1962; 11: 833
        • Michaels G.D.
        • Fukayama G.
        • Chin H.P.
        • Wheeler P.
        Technic for separation of plasma cholesterol esters for determination of iodine value, and of cholesterol.
        in: 4th ed. Proc. Soc. Exp. Biol. Med.98. 1958: 826
        • Youngburg G.E.
        • Youngburg M.V.
        Phosphorus metabolism. I. System of blood phosphorus analysis.
        J. Lab. Clin. Med. 1930; 16: 158
      1. Technicon Auto Analyzer Methodology for Determination of Total Glucose. Technicon Laboratory Method file rev. 2-11-60. Technicon Instruments Corporation, Chauncey, New York.

        • Michaels G.
        • Margen S.
        • Liebert G.
        • Kinsell L.W.
        Studies in fat metabolism. I. The colorimetric determination of ketone bodies in biological fluids.
        J. Clin. Invest. 1951; 30: 1483