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Abstract
The series of metabolic ward experiments, with 22 physically healthy men in each,
covered dietary cholesterol intakes from 50 to 1450 mg. daily, with all other variables
controlled. The serum-cholesterol data, plus the data from comparable experiments
reported from 4 other institutions, were analyzed in regard to average serum cholesterol
response (Δ Chol., mg./100 ml.) to changed cholesterol intake. Leastsquares solution,
using serum cholesterol responses in 19 sets of dietary cholesterol comparisons, gives
Δ Chol. = 1.5(Z2 − Z1), where the subscripts refer to the diets compared and Z is the square-root of the
dietary cholesterol, measured as mg./1000 Cal. The correlation between the average
Δ Chol. predicted and that observed is r = 0.95. The serum response was the same over
a wide range of dietary fat composition. Ordinary American diets range from about
![Math Eq]()
. These extremes correspond to an average difference of about ![Math Eq]()
if all other variables are constant. Change from ![Math Eq]()
to a cholesterol-free diet will cause an average fall of about ![Math Eq]()
of serum. But a 50 per cent decrease in dietary cholesterol will produce an average
decrease in the serum of only about ![Math Eq]()
. For the purpose of controlling the serum level, dietary cholesterol should not be
completely ignored but attention to this factor alone accomplishes little.
. These extremes correspond to an average difference of about 
if all other variables are constant. Change from 
to a cholesterol-free diet will cause an average fall of about 
of serum. But a 50 per cent decrease in dietary cholesterol will produce an average
decrease in the serum of only about 
. For the purpose of controlling the serum level, dietary cholesterol should not be
completely ignored but attention to this factor alone accomplishes little.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Received:
February 19,
1965
Footnotes
☆Aided by research grants from the U. S. Public Health Service (no. HE-04997 to A. K., no. HE-04401 to F. G. and J. T. A.)
Identification
Copyright
© 1965 Published by Elsevier Inc.
