Research Article| Volume 14, ISSUE 7, P759-765, July 1965

Serum cholesterol response to changes in the diet

II. The effect of cholesterol in the diet
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      The series of metabolic ward experiments, with 22 physically healthy men in each, covered dietary cholesterol intakes from 50 to 1450 mg. daily, with all other variables controlled. The serum-cholesterol data, plus the data from comparable experiments reported from 4 other institutions, were analyzed in regard to average serum cholesterol response (Δ Chol., mg./100 ml.) to changed cholesterol intake. Leastsquares solution, using serum cholesterol responses in 19 sets of dietary cholesterol comparisons, gives Δ Chol. = 1.5(Z2 − Z1), where the subscripts refer to the diets compared and Z is the square-root of the dietary cholesterol, measured as mg./1000 Cal. The correlation between the average Δ Chol. predicted and that observed is r = 0.95. The serum response was the same over a wide range of dietary fat composition. Ordinary American diets range from about Math Eq. These extremes correspond to an average difference of about Math Eq if all other variables are constant. Change from Math Eq to a cholesterol-free diet will cause an average fall of about Math Eq of serum. But a 50 per cent decrease in dietary cholesterol will produce an average decrease in the serum of only about Math Eq. For the purpose of controlling the serum level, dietary cholesterol should not be completely ignored but attention to this factor alone accomplishes little.
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