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Metabolic balance studies were undertaken during a 12-day fasting period in 6 mongrel and 4 Dalmatian dogs. No evidence of ketosis could be demonstrated during this period. Plasma bicarbonate concentration remained normal. Mean urinary ammonia and titratable acid fell markedly so that net acid excretion dropped from 59 to 23 mEq./day. Mean total urinary nitrogen excretion decreased from 7.2 to 3.3 Gm./day during starvation. A modest rise in urinary pH (0.18 unit) was observed during fasting. No change in urinary or plasma uric acid values could be demonstrated in either mongrel or Dalmatian dogs. Serum phospholipids, cholesterol and triglycerides were not modified during starvation while nonesterified fatty acids rose from 740 to 1000 μEq./L. These data contrast markedly with those observed in human subjects who develop ketosis, increased urinary ammonia and decreased uric acid excretion during fasting. Canine resistance to ketosis during starvation could be related to more efficient utilization of mobilized lipids.
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- Hyperuricemia in starvation.in: ed. 13. Proc. Soc. Exper. Biol. Med.118. 1965: 790
- Fasting as an introduction to the treatment of obesity.Metabolism. 1959; 8: 214
- Metabolic balance of obese subjects during fasting.Arch. Int. Med. 1966; 118: 3
- Extraction of lipids from serum.in: Sunderman F.W. Sunderman Jr., F.W. Lipids and the Steroid Hormones in Clinical Medicine. J. B. Lippincott Co, Philadelphia1960: 6
- The determination of uric acid in human blood.J. Biol. Chem. 1945; 158: 601
- Fat-mobilizing and ketogenic activity of urine extracts: relation to corticotrophin and growth hormone.Lancet. 1960; 2: 6
- Uric acid excretion and ketosis in fasting.Metabolism. 1965; 14: 1267
- A comparison of ketosis in man and dog.J. Biol. Chem. 1941; 138: 123
- Hepatic acetone body production in the dog during fasting and fat feeding.Amer. J. Physiol. 1940; 131: 10
- Uric acid excretion in obese subjects during periods of total fasting.Metabolism. 1964; 13: 303
- Effects of glycogen and epinephrine in fasted dogs.in: ed. 13. Proc. Soc. Exper. Biol. Med.121. 1966: 501
- A relation between nonesterified fatty acids in plasma and the metabolism of glucose.J. Clin. Invest. 1956; 35: 150
- Correction and control of intractable obesity.JAMA. 1962; 181: 309
- The colorimetric determination of phosphorus.J. Biol. Chem. 1925; 66: 375
- Observations concerning the causes of excess excretion of uric acid in the dalmatian dog.J. Biol. Chem. 1948; 175: 727
- Renal retention of uric acid induced by infusion of beta-hydroxybutyrate and acetoacetate.N. Eng. J. Med. 1965; 272: 351
- Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production.J. Clin. Invest. 1966; 45: 612
- Role of renal gluconeogenesis in regulation of renal ammonia production.Clin. Res. 1964; 12: 469
- Practical physiological chemistry.in: ed. 13. McGraw-Hill, New York1954: 839
- Rapid photoelectric method for the determination of glucose in blood and urine.J. Biol. Chem. 1937; 120: 51
- Fasting studies: VI. Distribution of nitrogen during a fast of one hundred and seventeen days.J. Biol. Chem. 1912; 11: 103
- The rate of isotopic carbon in kidney cortex synthetizing glucose from lactate.Biochem. J. 1966; 101: 242
- Acceleration of renal gluconeogenesis by ketone bodies and fatty acids.Biochem. J. 1965; 94: 712
- The effects of starvation, high fat diets, and ketone infusions on uric acid balance.Metabolism. 1965; 14: 186
- Elektrometrische mikrobestimmung von chlor in vollblut, serum and harn.Acta Paed. 1939; 26: 258
- Characteristics of potassium conservation by the dog kidney.Amer. J. Physiol. 1964; 206: 743
- Acute chloride depletion alkalosis: effect of anions on its maintenance and correction.Amer. J. Physiol. 1964; 207: 1279
- Chemical changes in the blood during fasting and subsequent refeeding.Amer. J. Physiol. 1924; 68: 477
- Hyperuricemia during total fasting. Renal factors.Arch. Int. Med. 1963; 112: 954
- Relation of renal amino and amide nitrogen extraction to ammonia production.Amer. J. Physiol. 1963; 204: 187
- Metabolic studies in prolonged fasting. I. Inorganic metabolism and kidney function.Metabolism. 1965; 14: 31
- Metabolic studies in prolonged fasting. II. Organic metabolism.Metabolism. 1965; 14: 47
- The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus, and nitrogen.J. Clin. Endocrin. 1945; 5: 367
- Metabolic observations during the treatment of obese patients by periods of total starvation.Metabolism. 1964; 13: 291
- A comparison of the effect of sodium and lithium on the absorption of glucose and xylose in vivo.Biochem. Biophys. Acta. 1965; 109: 312
- Starvation ketosis and uric acid excretion.Clin. Sci. 1964; 27: 209
- Micromethod for the direct determination of serum triglycerides.J. Lab. Clin. Med. 1957; 50: 152
- Studies of acidosis. XVI. The titration of organic acids in urine.J. Biol. Chem. 1920; 41: 567
- Effect of glucose on sodium excretion and renal concentrating ability after starvation in man.Metabolism. 1963; 12: 804
- Rapid estimation of free and total cholesterol.Amer. J. Clin. Pathol. 1954; 24: 1307
Received: August 18, 1967
☆This work was supported by grants from the Medical Research Council of Canada, the Department of National Health and Welfare, and the Canadian Arthritis and Rheumatism Society.
☆☆This work was done in partial fulfillment of the requirements for a Ph.D. degree in Investigative Medicine.
© 1968 Published by Elsevier Inc.