Changes in blood volume during absolute fasting with and without sodium chloride administration

      This paper is only available as a PDF. To read, Please Download here.


      In this study, investigations were made of the blood volume of 13 obese patients during 10 days of absolute fasting. In 7 of the patients, we found a decrease in blood volume between 200 and 1200 ml., corresponding to 14 per cent on the average. On the assumption that the changes occurred secondarily to a loss of sodium, the other 6 patients received 90 mEq. Na+ daily as sodium chloride during the fast. Under these conditions, the decrease in blood volume was significantly reduced, but the hypernatriuresis still occurred and weight loss continuously exceeded what could be expected on a caloric basis. Absolute fasting with sodium supply was found to eliminate the otherwise observed increase in blood volume under refeeding. However, the regimen could only diminish to some extent the weight gain in this situation. The possible mechanisms involved are discussed. It appears probable that changes in the production of aldosterone, as well as the hypernatriuresis produced, plays a great part in the problem.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic and Personal
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Metabolism - Clinical and Experimental
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Duncan G.G.
        • Jenson W.K.
        • Fraser R.I.
        • Cristofori F.C.
        Correction and control of intractable obesity.
        JAMA. 1962; 181: 309
        • Bloom W.L.
        Fasting as an introduction to the treatment of obesity.
        Metabolism. 1959; 8: 214
        • Natvig H.
        Landsforeningen for Kosthold og Helse. 1956; (Oslo)
        • Williams J.A.
        • Fine J.
        New Eng. J. Med. 1961; 264: 842
        • Bloom W.L.
        • Azar G.
        • Smith E.G.
        Changes in heart size and plasma volume during fasting.
        Metabolism. 1966; 15: 409
        • Bradley E.M.
        • Lecocq F.R.
        Body fluid compartments in obese males. Fasting and refeeding.
        Clin. Res. 1965; 13: 319
        • Gamble J.S.
        • Ross G.S.
        • Tissdall F.F.
        The metabolism of fixed base during fasting.
        J. Biol. Chem. 1923; 57: 633
        • Rapoport A.
        • From G.L.A.
        • Husdan H.
        Metabolic studies in prolonged fasting, I.
        Metabolism. 1965; 14: 31
        • Bloom W.L.
        Inhibition of salt excretion by carbohydrates.
        Arch. Intern. Med. 1962; 109: 80
        • Gersing A.
        • Bloom W.L.
        Glucose stimulation of salt retention in patients with aldosterone inhibition.
        Metabolism. 1962; 11: 329
        • Wright H.K.
        • Gann D.S.
        • Albertsen K.
        Effect of glucose on sodium excretion and renal concentrating ability after starvation in man.
        Metabolism. 1963; 12: 804
        • Haro E.N.
        • Blum S.F.
        • Faloon W.W.
        The glucagon response of fasting obese subjects.
        Metabolism. 1965; 14: 976
        • Bloom W.L.
        • Mitchell W.
        Salt excretion of fasting patients.
        Arch. Intern. Med. 1960; 106: 321
        • Stinebaugh B.J.
        • Schloeder F.X.
        Studies on the natriuresis of fasting.
        Metabolism. 1966; 15: 828
        • Schloeder F.X.
        • Stinebaugh B.J.
        Studies on the natriuresis of fasting.
        Metabolism. 1966; 15: 838
        • Spencer H.
        • Lewin I.
        • Samachson J.
        Changes in metabolism in obese persons during starvation.
        Amer. J. Med. 1966; 40: 27