Advertisement

Changes in body composition produced by prolonged total starvation and refeeding

  • D.L. Barnard
    Footnotes
    Affiliations
    Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    Search for articles by this author
  • J. Ford
    Footnotes
    Affiliations
    Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    Search for articles by this author
  • E.S. Garnett
    Footnotes
    Affiliations
    Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    Search for articles by this author
  • R.J. Mardell
    Footnotes
    Affiliations
    Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    Search for articles by this author
  • A.E. Whyman
    Footnotes
    Affiliations
    Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    Search for articles by this author
  • Author Footnotes
    1 D. L. Barnard, B.A., B.M., B.C.H. (Oxon.): Senior House Officer, Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    2 J. Ford, M.B., B.S. (Lond.): Research Registrar, Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    3 E. S. Garnett, M.B., B.S. (Lond.) M.R.C.P., M.R.C.P. (Ed.): Director, Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    4 R. J. Mardell, B.Sc. (Lond.): Biochemist, Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
    5 A. E. Whyman, B.Sc. (Leics.): Physicist, Wessex Regional Department of Nuclear Medicine, General Hospital, Southampton, England.
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Seven grossly obese patients were fasted for periods ranging from 10 to 45 weeks. Weight losses of up to 66.5 Kg. were obtained. Half of the reduction in weight was due to loss of lean tissue as shown by measurements of intracellular water and exchangeable potassium, and in two of the patients the exchangeable potassium fell as low as 1400 mEq. During refeeding the lean tissue mass increased rapidly in all of the patients, although five of them continued to lose fat.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Metabolism - Clinical and Experimental
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bloom W.L.
        Fasting as an introduction to the treatment of obesity.
        Metabolism. 1959; 8: 214
        • MacCuish A.C.
        • Munroe J.F.
        • Duncan L.I.P.
        Follow-up study of refractory obesity treated by fasting.
        Brit. Med. J. 1968; 1: 91
        • Drenick E.J.
        • Swendseid M.E.
        • Blahd W.H.
        • Tuttle S.G.
        Prolonged starvation as treatment for severe obesity.
        JAMA. 1964; 187: 140
        • Ball M.F.
        • Canary J.J.
        • Kyle L.H.
        Comparative effects of caloric restriction and total starvation on body composition in obesity.
        Ann. Int. Med. 1967; 67: 60
        • Bortz W.M.
        Editorial Comment.
        Metabolism. 1968; 17: 391
        • Thomson T.J.
        • Runcie J.
        • Miller V.
        Treatment of obesity by total fasting for up to 249 days.
        Lancet. 1966; 2: 992
        • Pace N.
        • Rathbun E.N.
        Studies on body composition.
        J. Biol. Chem. 1945; 158: 685
        • Birkenhager J.C.
        • Haak A.
        • Ackers J.G.
        Changes in body composition during treatment of obesity by intermittent starvation.
        Metabolism. 1968; 17: 391
        • Ashley B.C.E.
        • Whyte H.M.
        Metabolic studies in starvation.
        Aust. Ann. Med. 1961; 10: 92
        • Schloeder F.X.
        • Stinebaugh B.G.
        Electrolyte excretion in subjects fasting in tropical environment.
        Arch. Int. Med. 1965; 166: 866
        • Rapoport A.
        • From G.L.A.
        • Husdan H.
        Metabolic studies in prolonged fasting. I. Inorganic metabolism and kidney function.
        Metabolism. 1965; 14: 31
        • Benoit F.L.
        • Martin R.L.
        • Watten R.H.
        Changes in body composition during weight reduction in obesity.
        Ann. Int. Med. 1965; 63: 604
        • Drenick E.J.
        Total body potassium in obesity and during starvation.
        Clin. Res. 1966; 14: 183
        • Flear C.T.G.
        • Cook W.T.
        • Sivyer A.
        • Domenet J.
        Measurement of total exchangeable potassium.
        Clin. Chim. Acta. 1963; 8: 768
        • O'Toole J.J.
        • Cech R.F.
        • Peterson R.E.
        Observations on the course of urinary K-42 specific activity in fasting human subjects.
        Metabolism. 1966; 15: 1024
        • Moore F.D.
        • Olesen K.H.
        • McMurrey J.D.
        • Parker H.V.
        • Ball M.R.
        • Boyden C.M.
        The body cell mass and its supporting environment.
        Saunders, Philadelphia1963
        • Garnett E.S.
        • Ford J.
        • Golding P.L.
        • Mardell R.J.
        • Whyman A.E.
        The mobilisation of osmotically inactive sodium during total starvation in man.
        Clin. Sci. 1968; 35: 93
      1. Garnett, E. S.: Personal communication, 1968.

        • Nagant De Deuxchaisnes C.
        • Collet R.A.
        • Busset R.
        • Mach R.S.
        Exchangeable potassium in wasting, amyotrophy, heart disease and cirrhosis of the liver.
        Lancet. 1961; 1: 179
        • Staffurth J.S.
        Exchangeable potassium in hypokalaemia.
        Postgrad. Med. J. 1964; 40: 4
        • Hermann L.S.
        • Iversen M.
        Death during therapeutic starvation.
        Lancet. 1968; 2: 217