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Effect of thiamine on serotonin levels in magnesium-deficient animals

  • Yoshinori Itokawa
    Footnotes
    Affiliations
    Department of Hygiene and Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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  • Chikako Tanaka
    Footnotes
    Affiliations
    Department of Hygiene and Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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  • Mieko Kimura
    Footnotes
    Affiliations
    Department of Hygiene and Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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  • Author Footnotes
    1 Yoshinori Itokawa, M.D.: Instructor, Department of Hygiene, Faculty of Medicine, Kyoto University, Kyoto, Japan.
    2 Chikako Tanaka, M.D.: Lecturer, Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
    3 Mieko Kimura, M.S.: Research Associate, Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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      Abstract

      To clarify the relationship between thiamine metabolism and peripheral vasodilation symptoms seen in the early stages of dietary magnesium deficiency, various synthetic diets were administered to rats. After a 4-wk period of thiamine excess and magnesium-deficient diet, blood serotonin levels increased significantly. A thiamine-deficient and magnesium-deficient diet revealed no elevation of blood serotonin. Serotonin in stomach and intestine increased in the excess-thiamine, magnesium-deficient group. Blood magnesium concentration decreased markedly in thiamine-supplemented, magnesium-deficient groups but not in the thiamine-deficient magnesium-deficient group. A possible explanation of the mechanism is presented.
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